Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.69 |
| ▸ | NPC1 | O15118 | 1/20 | 0.69 |
| ▸ | HPGD | P15428 | 1/20 | 0.69 |
| ▸ | CASP3 | P42574 | 1/20 | 0.69 |
| ▸ | RAB9A | P51151 | 1/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.69 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.69 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.69 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.69 |
| ▸ | ATG4B | Q9Y4P1 | 12/20 | 0.65 |
| ▸ | PLA2G1B | P04054 | 11/20 | 0.65 |
| ▸ | THRA | P10827 | 2/20 | 0.63 |
| ▸ | THRB | P10828 | 2/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | RECQL | P46063 | 1/20 | 0.63 |
| ▸ | TRPM2 | O94759 | 2/20 | 0.59 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.59 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL846033 | 1.00 | ALDH1A1 (0.69) | ALDH1A1KDM4ENPC1HPGDCASP3 | |
| SCHEMBL11765995 | 0.98 | ALDH1A1 (0.67) | ALDH1A1KDM4ENPC1HPGDCASP3 | |
| SCHEMBL19460591 | 0.98 | ALDH1A1 (0.67) | ALDH1A1KDM4ENPC1HPGDCASP3 | |
| SCHEMBL3684326 | 0.98 | ALDH1A1 (0.67) | ALDH1A1KDM4ENPC1HPGDCASP3 | |
| SCHEMBL6279557 | 0.98 | ALDH1A1 (0.67) | ALDH1A1KDM4ENPC1HPGDCASP3 | |
| SCHEMBL6287182 | 0.98 | ALDH1A1 (0.67) | ALDH1A1KDM4ENPC1HPGDCASP3 | |
| SCHEMBL6279559 | 0.98 | ALDH1A1 (0.67) | ALDH1A1KDM4ENPC1HPGDCASP3 | |
| Hydrochloric Acid SCHEMBL11766313 | 0.98 | ALDH1A1 (0.67) | ALDH1A1KDM4ENPC1HPGDCASP3 | |
| SCHEMBL489898 | 0.98 | ALDH1A1 (0.67) | ALDH1A1KDM4ENPC1HPGDCASP3 | |
| SCHEMBL3025061 | 0.98 | ALDH1A1 (0.67) | ALDH1A1KDM4ENPC1HPGDCASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888596-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2014-10-22 | — | — | EP | disclosed |
| US-8772307-B2 | Substituted spiro compounds and their use for producing pain-relief medicaments | GRUENENTHAL GMBH (DE) | 2014-07-08 | — | — | US | disclosed |
| US-8772307-B2 | Substituted spiro compounds and their use for producing pain-relief medicaments | GRUENENTHAL GMBH (DE) | 2014-07-08 | — | — | US | disclosed |
| US-8394828-B2 | Quinoline-derived amide modulators of vanilloid VR1 receptor | JANSSEN PHARMACEUTICA, NV (BE) | 2013-03-12 | — | — | US | disclosed |
| US-8394828-B2 | Quinoline-derived amide modulators of vanilloid VR1 receptor | JANSSEN PHARMACEUTICA, NV (BE) | 2013-03-12 | — | — | US | disclosed |
| US-8394828-B2 | Quinoline-derived amide modulators of vanilloid VR1 receptor | JANSSEN PHARMACEUTICA, NV (BE) | 2013-03-12 | — | — | US | disclosed |
| EP-1603883-B1 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-28 | — | — | EP | disclosed |
| EP-1603883-B1 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-28 | — | — | EP | disclosed |
| EP-2308848-A1 | Quinoline-derived amide modulators of vanilloid VR1 receptor | Janssen Pharmaceutica NV (BE) | 2011-04-13 | — | — | EP | disclosed |
| EP-2308848-A1 | Quinoline-derived amide modulators of vanilloid VR1 receptor | Janssen Pharmaceutica NV (BE) | 2011-04-13 | — | — | EP | disclosed |
| EP-1284260-A1 | TYROSINE PHOSPHATASE INHIBITORS | Takeda Chemical Industries, Ltd. (JP) | 2003-02-19 | — | — | EP | disclosed |
| US-5459134-A | Leukotriene antagonists; phospholipase, 5-alpha-reductase, and aldose reductase inhibitors | ONO PHARMACEUTICAL CO., LTD. (JP) | 1995-10-17 | — | — | US | disclosed |
| US-5446058-A | Leukotriene antagonists, 5-alpha-reductase inhibitors | ONO PHARMACEUTICAL CO., LTD. (JP) | 1995-08-29 | — | — | US | disclosed |
| EP-0463638-B1 | Aminophenyl derivatives | ONO PHARMACEUTICAL CO (JP) | 1995-05-24 | — | — | EP | disclosed |
| EP-0173516-B1 | (Fused)benz(thio)amides | ONO PHARMACEUTICAL CO (JP) | 1993-12-01 | — | — | EP | disclosed |
| US-4939141-A | (Fused) benz (thio) amides and pharmaceutical compositions, thereof | ONO PHARMACEUTICAL CO., LTD. (JP) | 1990-07-03 | — | — | US | disclosed |
| US-4847275-A | ENZYME INHIBITOR, LEUKOTRIENE ANTAGONIST | ONO PHARMACEUTICAL CO., LTD. (JP) | 1989-07-11 | — | — | US | disclosed |
| US-4780469-A | (Fused) benz(thio)amides and pharmaceutical use | ONO PHARMACEUTICAL CO., LTD. (JP) | 1988-10-25 | — | — | US | disclosed |
| EP-0173516-A2 | (Fused)benz(thio)amides | ONO PHARMACEUTICAL CO., LTD. (JP) | 1986-03-05 | — | — | EP | disclosed |
| US-4061587-A | Liquid crystalline cinnamic acid esters | HOFFMANN-LA ROCHE INC. (US) | 1977-12-06 | — | — | US | disclosed |