Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 7/20 | 1.00 |
| ▸ | MEN1 | O00255 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 3/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 1/20 | 1.00 |
| ▸ | FNTA | P49354 | 6/20 | 0.49 |
| ▸ | FNTB | P49356 | 6/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29373792 | 1.00 | TACR1 (1.00) | TACR1MEN1KMT2ACYP3A4MAPT | |
| SCHEMBL4349316 | 1.00 | TACR1 (1.00) | TACR1MEN1KMT2ACYP3A4MAPT | |
| SCHEMBL7551020 | 1.00 | TACR1 (1.00) | TACR1MEN1KMT2ACYP3A4MAPT | |
| SCHEMBL14434342 | 1.00 | TACR1 (1.00) | TACR1MEN1KMT2ACYP3A4MAPT | |
| SCHEMBL9729727 | 0.90 | TACR1 (0.82) | TACR1MEN1KMT2ACYP3A4MAPT | |
| SCHEMBL21286546 | 0.90 | TACR1 (0.81) | TACR1MEN1KMT2ACYP3A4MAPT | |
| SCHEMBL9729596 | 0.89 | TACR1 (0.80) | TACR1MEN1KMT2ACYP3A4MAPT | |
| SCHEMBL9729430 | 0.89 | TACR1 (0.80) | TACR1MEN1KMT2ACYP3A4MAPT | |
| SCHEMBL9731121 | 0.84 | TACR1 (0.73) | TACR1MEN1KMT2ACYP3A4MAPT | |
| SCHEMBL9729517 | 0.83 | TACR1 (0.71) | TACR1MEN1KMT2ACYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999007413-A1 | SUBSTANCE P INHIBITORS IN COMBINATION WITH NMDA-BLOCKERS FOR TREATING PAIN | ALGOS PHARMACEUTICAL CORPORATION (US) | 1999-02-18 | — | — | WO | claimed |
| EP-0429366-B1 | Isoindolone derivatives, their preparation and pharmaceutical compositions containing them | RHONE POULENC SANTE (FR) | 1994-03-16 | — | — | EP | claimed |
| US-5102667-A | Antiallergens, antiinflammatory agents, nervous system disorders, immunology, psychological disorders | RHONE-POULENC SANTE (FR) | 1992-04-07 | — | — | US | claimed |
| WO-1999007413-A1 | SUBSTANCE P INHIBITORS IN COMBINATION WITH NMDA-BLOCKERS FOR TREATING PAIN | ALGOS PHARMACEUTICAL CORPORATION (US) | 1999-02-18 | — | — | WO | disclosed |
| US-5112988-A | ISOINDOLONE DERIVATIVES | RHONE-POULENC SANTE (FR) | 1992-05-12 | — | — | US | disclosed |
| US-5102667-A | Antiallergens, antiinflammatory agents, nervous system disorders, immunology, psychological disorders | RHONE-POULENC SANTE (FR) | 1992-04-07 | — | — | US | disclosed |