Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 4/20 | 0.63 |
| ▸ | CA2 | P00918 | 4/20 | 0.63 |
| ▸ | PPARA | Q07869 | 2/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.52 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.52 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | RORC | P51449 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.45 |
| ▸ | RXRA | P19793 | 1/20 | 0.45 |
| ▸ | RXRB | P28702 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8461643 | 0.85 | CA1 (0.74) | CA1CA2EPHX2NR1H4KMT2A | |
| SCHEMBL103563 | 0.82 | SRD5A2 (0.57) | CA1CA2EPHX2NR1H4ALDH1A1 | |
| SCHEMBL4418236 | 0.82 | CA1 (0.59) | CA1CA2FFAR1ALDH1A1HDAC1 | |
| SCHEMBL7820479 | 0.80 | FFAR1 (0.69) | CA1CA2PPARAFFAR1ALDH1A1 | |
| SCHEMBL20236549 | 0.80 | FFAR1 (0.69) | CA1CA2PPARAEPHX2NR1H4 | |
| SCHEMBL11414793 | 0.77 | FFAR1 (0.67) | CA1CA2FFAR1ALDH1A1POLB | |
| SCHEMBL11413950 | 0.77 | ALDH1A1 (0.69) | CA1CA2FFAR1ALDH1A1HDAC1 | |
| SCHEMBL16550429 | 0.77 | FFAR1 (0.67) | CA1CA2FFAR1ALDH1A1POLB | |
| SCHEMBL2643145 | 0.77 | CA1 (1.00) | CA1CA2EPHX2NR1H4ALDH1A1 | |
| SCHEMBL8461966 | 0.76 | CA1 (0.55) | CA1CA2PPARAFFAR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999048529-A1 | RETINOID-GLITAZONE COMBINATIONS | WARNER-LAMBERT COMPANY (US) | 1999-09-30 | — | — | WO | disclosed |
| EP-0808159-A1 | USE OR RETINOIDS TO LOWER PLASMA LEVELS OF LIPOPROTEIN (a) | WARNER-LAMBERT COMPANY (US) | 1997-11-26 | — | — | EP | disclosed |
| WO-1996024344-A1 | USE OF RETINOIDS TO LOWER PLASMA LEVELS OF LIPOPROTEIN (a) | WARNER-LAMBERT COMPANY (US) | 1996-08-15 | — | — | WO | disclosed |
| US-5489611-A | ADMINISTERING A RETINOID COMPOUND | WARNER-LAMBERT COMPANY (US) | 1996-02-06 | — | — | US | disclosed |