SCHEMBL8461192

SCHEMBL8461192

Cc1cc(C)cc(C(=O)N(NC(=O)c2cccc(C)c2C)C(C)(C)C)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ABCB1 P08183 7/20 0.81
CYP3A4 P08684 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL32672049 1.00 ABCB1 (0.81) ABCB1CYP3A4
SCHEMBL8772420 0.91 ABCB1 (0.67) ABCB1CYP3A4
SCHEMBL16077544 0.89 ABCB1 (0.72) ABCB1CYP3A4
SCHEMBL10718829 0.89 ABCB1 (0.79) ABCB1CYP3A4
SCHEMBL5064009 0.89 ABCB1 (0.73) ABCB1CYP3A4
SCHEMBL10139344 0.89 ABCB1 (0.73) ABCB1CYP3A4
SCHEMBL10722660 0.88 ABCB1 (0.62) ABCB1CYP3A4
SCHEMBL10720118 0.88 ABCB1 (0.77) ABCB1CYP3A4
SCHEMBL20146003 0.88 ABCB1 (0.77) ABCB1CYP3A4
SCHEMBL10720303 0.88 ABCB1 (0.62) ABCB1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0712575-B1 Synergistic insecticidal compositions ROHM & HAAS (US) 1999-06-09 EP claimed
EP-0632958-B1 Composition and method for protecting keratinous material from keratin digesting insects ROHM & HAAS (US) 1998-02-25 EP claimed
EP-0639559-B1 Preparation of 1,2-diacyl-2-(t-alkyl)hydrazines ROHM & HAAS (US) 1997-10-15 EP claimed
EP-0712575-A1 Synergistic insecticidal compositions ROHM AND HAAS COMPANY (US) 1996-05-22 EP claimed
EP-0639559-A1 Preparation of 1,2-diacyl-2-(t-alkyl)hydrazines ROHM AND HAAS COMPANY (US) 1995-02-22 EP claimed
EP-0632958-A1 Composition and method for protecting keratinous material from keratin digesting insects ROHM AND HAAS COMPANY (US) 1995-01-11 EP claimed
US-20180213776-A1 COMPOSITIONS FOR CONTROLLING MOSQUITO POPULATIONS PRESIDENT AND FELLOWS OF HARVARD COLLEGE 2018-08-02 US disclosed
EP-0712575-B1 Synergistic insecticidal compositions ROHM & HAAS (US) 1999-06-09 EP disclosed
EP-0632958-B1 Composition and method for protecting keratinous material from keratin digesting insects ROHM & HAAS (US) 1998-02-25 EP disclosed
EP-0639559-B1 Preparation of 1,2-diacyl-2-(t-alkyl)hydrazines ROHM & HAAS (US) 1997-10-15 EP disclosed
US-5571829-A CYTOCHROME P450 ENZYME INHIBITOR AND AN N,N'-DIBENZOYL-N'-TERT-ALKYL-HYDRAZINE ROHM AND HAAS COMPANY (US) 1996-11-05 US disclosed
EP-0712575-A1 Synergistic insecticidal compositions ROHM AND HAAS COMPANY (US) 1996-05-22 EP disclosed
US-5510363-A COMPRISING DINICONAZOLE ENZYME INHIBITOR ROHM AND HAAS COMPANY (US) 1996-04-23 US disclosed
US-5506251-A APPLYING N'-(3,5-DIMETHYLBENZOYL)-N-(4-ETHYLBENZOYL)-N'-TERT-BUTYL HYDRAZINE AND A CYTOCHROME P450 ENZYME INHIBITOR: FENBUCONAZOLE OR MYCLOBUTANIL ROHM AND HAAS COMPANY (US) 1996-04-09 US disclosed
EP-0639559-A1 Preparation of 1,2-diacyl-2-(t-alkyl)hydrazines ROHM AND HAAS COMPANY (US) 1995-02-22 EP disclosed
EP-0632958-A1 Composition and method for protecting keratinous material from keratin digesting insects ROHM AND HAAS COMPANY (US) 1995-01-11 EP disclosed
US-5358967-A Wool protecting compositons and methods ROHM AND HAAS COMPANY (US) 1994-10-25 US disclosed
EP-0236618-A2 Insecticidal N'-substituted-N,N'-diacylhydrazines ROHM AND HAAS COMPANY (US) 1987-09-16 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180213776-A1 COMPOSITIONS FOR CONTROLLING MOSQUITO POPULATIONS CYP46A1, CYP17A1, CYP11A1 ABCB1 3055/4885CYP3A4 179/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.