Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 5/20 | 0.54 |
| ▸ | FFAR1 | O14842 | 6/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | PPARA | Q07869 | 2/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 2/20 | 0.44 |
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10683704 | 0.81 | PPARG (0.56) | PPARGFFAR1MAPTALDH1A1NPSR1 | |
| SCHEMBL10368995 | 0.81 | ALDH1A1 (0.54) | PPARGFFAR1MAPTALDH1A1NPSR1 | |
| SCHEMBL166570 | 0.79 | PPARG (0.74) | PPARGFFAR1MAPTALDH1A1NPSR1 | |
| SCHEMBL10689114 | 0.78 | PPARG (0.53) | PPARGFFAR1MAPTALDH1A1NPSR1 | |
| SCHEMBL10686384 | 0.77 | PPARG (0.52) | PPARGFFAR1MAPTALDH1A1NPSR1 | |
| SCHEMBL10686431 | 0.77 | PPARG (0.52) | PPARGFFAR1MAPTALDH1A1NPSR1 | |
| SCHEMBL6903859 | 0.77 | PPARG (0.52) | PPARGFFAR1MAPTALDH1A1NPSR1 | |
| SCHEMBL10690190 | 0.77 | PPARG (0.52) | PPARGFFAR1MAPTALDH1A1NPSR1 | |
| SCHEMBL6866703 | 0.77 | PPARG (0.71) | PPARGFFAR1MAPTALDH1A1NPSR1 | |
| SCHEMBL8460436 | 0.76 | PPARG (0.51) | PPARGFFAR1MAPTALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999059586-A1 | THIAZOLIDINE AND OXAZOLIDINE DERIVATIVES FOR THE TREATMENT OF ACUTE MYOCARDIAL INFARCTION AND INHIBITION OF CARDIOMYOCYTE APOPTOSIS | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1999-11-25 | — | — | WO | claimed |
| EP-0207605-B1 | HYPOGLYCEMIC THIAZOLIDINEDIONES | PFIZER INC. (US) | 1990-02-07 | — | — | EP | disclosed |
| WO-1986007056-A1 | HYPOGLYCEMIC THIAZOLIDINEDIONES | PFIZER INC. (US) | 1986-12-04 | — | — | WO | disclosed |