Acetic Acid

Acetic Acid

SCHEMBL8462148

CC(=O)O.Cl.O=[N+]([O-])NN(c1ccccc1)[N+](=O)[O-]

nearest known ligand 0.41

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ATM Q13315 2/20 0.41
ALDH1A1 P00352 6/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
HTT P42858 1/20 0.36
MEN1 O00255 3/20 0.36
KMT2A Q03164 3/20 0.36
L3MBTL1 Q9Y468 2/20 0.36
CRHBP P24387 2/20 0.36
CRHR2 Q13324 2/20 0.36
TLR9 Q9NR96 2/20 0.36
MTNR1A P48039 1/20 0.36
MTNR1B P49286 1/20 0.36
RAB9A P51151 1/20 0.35
LMNA P02545 2/20 0.35
MITF O75030 1/20 0.35
MAPT P10636 1/20 0.35
FBP1 P09467 1/20 0.35
NPSR1 Q6W5P4 2/20 0.34
TSHR P16473 1/20 0.34
S1PR4 O95977 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Methyl Alcohol SCHEMBL27709287 0.91 ATM (0.41) ATMALDH1A1SMN1; SMN2MEN1KMT2A
Hydrochloric Acid SCHEMBL176982 0.91 ALDH1A1 (0.41) ATMALDH1A1SMN1; SMN2MEN1KMT2A
Acetic Acid SCHEMBL27805392 0.91 ATM (0.38) ATMALDH1A1SMN1; SMN2HTTMEN1
SCHEMBL38002 0.89 ALDH1A1 (0.42) ATMALDH1A1SMN1; SMN2MEN1KMT2A
Alcohol SCHEMBL27523839 0.87 ALDH1A1 (0.40) ATMALDH1A1SMN1; SMN2MEN1KMT2A
Formaldehyde SCHEMBL2941056 0.86 ALDH1A1 (0.40) ATMALDH1A1SMN1; SMN2MEN1KMT2A
Phosphoric Acid SCHEMBL27824259 0.85 ALDH1A1 (0.37) ATMALDH1A1SMN1; SMN2HTTMEN1
Acetaldehyde SCHEMBL1704750 0.85 ALDH1A1 (0.37) ATMALDH1A1SMN1; SMN2MEN1KMT2A
Sulfuric Acid SCHEMBL8936551 0.85 MEN1 (0.38) ATMALDH1A1SMN1; SMN2MEN1KMT2A
Acetonitrile SCHEMBL1262524 0.83 ALDH1A1 (0.36) ATMALDH1A1SMN1; SMN2MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1999021006-A9 PHARMACEUTICAL GRADE VALERIAN, BLACK COHOSH, VITEX AGNUS-CASTUS, BILBERRY AND MILK THISTLE PHARMAPRINT INC (US) 1999-07-08 WO disclosed
WO-1999021006-A1 PHARMACEUTICAL GRADE VALERIAN, BLACK COHOSH, VITEX AGNUS-CASTUS, BILBERRY AND MILK THISTLE PHARMAPRINT, INC. (US) 1999-04-29 WO disclosed