Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 15/20 | 0.62 |
| ▸ | CFTR | P13569 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL846100 | 0.80 | CFTR (0.47) | TRPV1CFTRPOLBRAB9APDE10A | |
| SCHEMBL846651 | 0.77 | TRPV1 (1.00) | TRPV1RAB9A | |
| SCHEMBL20509079 | 0.75 | RAB9A (0.48) | TRPV1LMNAPOLBTSHRRAB9A | |
| SCHEMBL6114503 | 0.74 | PDE10A (0.60) | TRPV1LMNAPOLBTSHRRAB9A | |
| SCHEMBL846121 | 0.74 | TRPV1 (0.98) | TRPV1RAB9A | |
| SCHEMBL2158482 | 0.74 | TRPV1 (0.50) | TRPV1 | |
| SCHEMBL846096 | 0.73 | TRPV1 (1.00) | TRPV1RAB9A | |
| SCHEMBL846630 | 0.73 | TRPV1 (1.00) | TRPV1RAB9A | |
| SCHEMBL846134 | 0.73 | TRPV1 (1.00) | TRPV1RAB9A | |
| SCHEMBL846650 | 0.73 | TRPV1 (1.00) | TRPV1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603883-B1 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-28 | — | — | EP | disclosed |
| EP-2308848-A1 | Quinoline-derived amide modulators of vanilloid VR1 receptor | Janssen Pharmaceutica NV (BE) | 2011-04-13 | — | — | EP | disclosed |