Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 12/20 | 0.75 |
| ▸ | KDR | P35968 | 6/20 | 0.53 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL845817 | 0.86 | TRPV1 (0.74) | TRPV1KDRTMPRSS4KDM4E | |
| SCHEMBL846116 | 0.86 | TRPV1 (1.00) | TRPV1KDRKDM4E | |
| SCHEMBL846740 | 0.83 | TRPV1 (0.72) | TRPV1KDRTMPRSS4KDM4E | |
| SCHEMBL845816 | 0.82 | KDR (0.56) | TRPV1KDRTMPRSS4KDM4E | |
| SCHEMBL846237 | 0.80 | TRPV1 (0.74) | TRPV1KDRTMPRSS4 | |
| SCHEMBL845644 | 0.79 | TRPV1 (0.72) | TRPV1KDRTMPRSS4KDM4E | |
| SCHEMBL845885 | 0.79 | TRPV1 (0.73) | TRPV1KDM4E | |
| SCHEMBL845924 | 0.79 | TRPV1 (0.79) | TRPV1KDRKDM4E | |
| SCHEMBL846826 | 0.79 | KDR (0.58) | TRPV1KDRTMPRSS4KDM4E | |
| SCHEMBL6384026 | 0.76 | TRPV1 (0.54) | TRPV1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603883-B1 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-28 | — | — | EP | disclosed |