SCHEMBL8464434

SCHEMBL8464434

O=Ic1c(CC(=O)O)cc([N+](=O)[O-])cc1CC(=O)O

nearest known ligand 0.53

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.53
HTT P42858 3/20 0.41
POLB P06746 1/20 0.41
SMN1; SMN2 Q16637 2/20 0.38
CYP3A4 P08684 1/20 0.38
CA1 P00915 1/20 0.37
CA2 P00918 1/20 0.37
CYP19A1 P11511 1/20 0.36
AMY1A P0DUB6 1/20 0.36
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
GALR3 O60755 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
LMNA P02545 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
TP53 P04637 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8462320 0.92 CYP1A2 (0.60) CYP1A2HTTPOLBSMN1; SMN2CYP3A4
SCHEMBL8462410 0.79 CYP1A2 (0.60) CYP1A2HTTCYP3A4AMY1AMEN1
SCHEMBL8460594 0.76 CYP1A2 (0.47) CYP1A2MEN1KMT2A
SCHEMBL8463416 0.76 CYP1A2 (0.53) CYP1A2HTTPOLBSMN1; SMN2CYP3A4
SCHEMBL8462599 0.76 POLB (0.50) POLBCA2MEN1KMT2ALMNA
SCHEMBL6292292 0.75 CYP1A2 (0.75) CYP1A2HTTSMN1; SMN2CYP3A4AMY1A
SCHEMBL8820382 0.75 ALDH1A1 (0.58) CYP1A2HTTPOLBSMN1; SMN2CYP3A4
SCHEMBL9599309 0.75 CYP1A2 (0.51) CYP1A2HTTPOLBSMN1; SMN2CYP3A4
SCHEMBL28017843 0.75 CYP1A2 (0.51) CYP1A2HTTPOLBSMN1; SMN2CYP3A4
SCHEMBL3831751 0.75 CYP1A2 (0.51) CYP1A2HTTPOLBSMN1; SMN2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0745326-B1 Stabilization of aqueous 3-isothiazolone solutions ROHM & HAAS (US) 1999-09-22 EP disclosed
US-5594017-A WITH AN IODOSYL OR IODYL COMPOUND ROHM AND HAAS COMPANY (US) 1997-01-14 US disclosed
EP-0745326-A1 Stabilization of aqueous 3-isothiazolone solutions ROHM AND HAAS COMPANY (US) 1996-12-04 EP disclosed