Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.64 |
| ▸ | MAOB | P27338 | 2/20 | 0.50 |
| ▸ | CYSLTR1 | Q9Y271 | 3/20 | 0.45 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.45 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.45 |
| ▸ | CTSD | P07339 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9578104 | 0.88 | MAPT (0.64) | MAPTCYP2C9CYP2C19SMN1; SMN2TDP1 | |
| SCHEMBL28350864 | 0.86 | CTSD (0.52) | MAPTCYP2C9CYP2C19SMN1; SMN2TDP1 | |
| SCHEMBL17694446 | 0.85 | MEN1 (0.50) | MAPTCYP2C9CYP2C19SMN1; SMN2TDP1 | |
| SCHEMBL9123233 | 0.84 | MAPT (0.71) | MAPTCYP2C9CYP2C19SMN1; SMN2TDP1 | |
| SCHEMBL9120538 | 0.82 | MAPT (0.67) | MAPTCYP2C9CYP2C19SMN1; SMN2TDP1 | |
| SCHEMBL8465903 | 0.81 | MAPT (0.70) | MAPTCYP2C9CYP2C19SMN1; SMN2TDP1 | |
| SCHEMBL11396021 | 0.81 | MAOB (0.50) | MAPTCYP2C9L3MBTL1MAOBCYSLTR1 | |
| SCHEMBL5516591 | 0.81 | MAPT (0.56) | MAPTCYP2C9CYP2C19SMN1; SMN2TDP1 | |
| SCHEMBL5516584 | 0.81 | MAPT (0.56) | MAPTCYP2C9CYP2C19SMN1; SMN2TDP1 | |
| SCHEMBL10765338 | 0.80 | SRD5A1 (0.43) | MAPTCYP2C9CYP2C19SMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0682662-B1 | BICYCLIC CARBOXYLIC ACID LEUKOTRIENE B4 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 1999-08-18 | — | — | EP | disclosed |
| EP-0682662-A1 | BICYCLIC CARBOXYLIC ACID LEUKOTRIENE B 4? ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1995-11-22 | — | — | EP | disclosed |
| US-5457124-A | Antiinflammatory agent | HOFFMANN-LA ROCHE INC. (US) | 1995-10-10 | — | — | US | disclosed |
| WO-1995015956-A1 | BICYCLIC CARBOXYLIC ACID LEUKOTRIENE B4 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1995-06-15 | — | — | WO | disclosed |