Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 10/20 | 0.55 |
| ▸ | NPC1 | O15118 | 9/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.54 |
| ▸ | MITF | O75030 | 1/20 | 0.54 |
| ▸ | XBP1 | P17861 | 1/20 | 0.54 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.54 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL846516 | 0.89 | TRPV1 (0.65) | KDRRAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL651159 | 0.87 | KDR (0.74) | KDRRAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL13763264 | 0.85 | KDR (0.71) | KDRRAB9ANPC1SMN1; SMN2KDM4E | |
| SCHEMBL846245 | 0.80 | TRPV1 (0.56) | KDRRAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL4899760 | 0.80 | KDR (0.60) | KDRRAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL845922 | 0.79 | KDR (0.62) | KDRRAB9ANPC1SMN1; SMN2KDM4E | |
| SCHEMBL846873 | 0.77 | SMN1; SMN2 (0.59) | KDRRAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL846872 | 0.77 | SMN1; SMN2 (0.59) | KDRRAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL27866684 | 0.77 | NPC1 (0.80) | KDRRAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL23880568 | 0.76 | KDR (0.70) | KDRRAB9ANPC1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603883-B1 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-28 | — | — | EP | claimed |