Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.65 |
| ▸ | KDR | P35968 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 7/20 | 0.52 |
| ▸ | NPC1 | O15118 | 6/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.52 |
| ▸ | MITF | O75030 | 1/20 | 0.52 |
| ▸ | XBP1 | P17861 | 1/20 | 0.52 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.52 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | ADCY6 | O43306 | 1/20 | 0.47 |
| ▸ | ADCY3 | O60266 | 1/20 | 0.47 |
| ▸ | ADCY9 | O60503 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL846477 | 0.89 | KDR (0.59) | TRPV1KDRRAB9ANPC1KDM4E | |
| SCHEMBL13763264 | 0.82 | KDR (0.71) | TRPV1KDRRAB9ANPC1KDM4E | |
| SCHEMBL846245 | 0.80 | TRPV1 (0.56) | TRPV1KDRRAB9ANPC1KDM4E | |
| SCHEMBL846963 | 0.80 | TRPV1 (0.64) | TRPV1KDRRAB9ANPC1KDM4E | |
| SCHEMBL651159 | 0.79 | KDR (0.74) | TRPV1KDRRAB9ANPC1KDM4E | |
| SCHEMBL846396 | 0.79 | TRPV1 (1.00) | TRPV1KDRRAB9ANPC1KDM4E | |
| SCHEMBL4899760 | 0.77 | KDR (0.60) | TRPV1KDRRAB9ANPC1KDM4E | |
| SCHEMBL13544369 | 0.75 | TRPV1 (0.78) | TRPV1KDRRAB9ANPC1KDM4E | |
| SCHEMBL846474 | 0.75 | TRPV1 (0.70) | TRPV1KDRRAB9ANPC1KDM4E | |
| SCHEMBL846062 | 0.73 | TRPV1 (0.67) | TRPV1KDRRAB9ANPC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603883-B1 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-28 | — | — | EP | claimed |