SCHEMBL8464944

SCHEMBL8464944

COc1ccc(C(=O)N(Cl)Cl)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES2 O00748 2/20 0.59
CES1 P23141 2/20 0.59
CA1 P00915 6/20 0.57
CA2 P00918 6/20 0.57
HPGD P15428 2/20 0.56
KDM4E B2RXH2 1/20 0.56
PARP10 Q53GL7 2/20 0.55
PARP1 P09874 1/20 0.55
PARP2 Q9UGN5 1/20 0.55
PARP4 Q9UKK3 1/20 0.55
PLK1 P53350 1/20 0.52
MAPT P10636 2/20 0.50
GSK3B P49841 1/20 0.50
MEN1 O00255 1/20 0.50
LMNA P02545 1/20 0.50
MAPK1 P28482 1/20 0.50
RAB9A P51151 1/20 0.50
KMT2A Q03164 1/20 0.50
NPSR1 Q6W5P4 1/20 0.50
RXFP1 Q9HBX9 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30527863 0.83 CES2 (0.64) CES2CES1CA1CA2HPGD
SCHEMBL1659309 0.81 HPGD (0.73) CES2CES1CA1CA2HPGD
SCHEMBL5858910 0.81 HPGD (0.62) CES2CES1CA1CA2HPGD
SCHEMBL11212295 0.81 CES2 (0.61) CES2CES1CA1CA2HPGD
SCHEMBL11685994 0.79 CES2 (0.53) CES2CES1CA1CA2HPGD
SCHEMBL8464986 0.79 PARP10 (0.59) HPGDKDM4EPARP10PLK1MAPT
SCHEMBL10049412 0.78 CA1 (0.59) CES2CES1CA1CA2HPGD
SCHEMBL2112462 0.78 KDM4E (0.59) CES2CES1CA1CA2HPGD
SCHEMBL286256 0.78 CES2 (0.57) CES2CES1CA1CA2HPGD
SCHEMBL12083940 0.76 CA1 (0.57) CES2CES1CA1CA2HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0946093-A2 FUNGICIDAL COMPOSITIONS BASED ON (N-PHENYLACETYL-N-2,6-XYLYL)METHYL ALANINATE ISAGRO S.p.A. (IT) 1999-10-06 EP claimed
WO-1998026654-A2 FUNGICIDAL COMPOSITIONS BASED ON (N-PHENYLACETYL-N-2,6-XYLYL)METHYL ALANINATE ISAGRO S.P.A. (IT) 1998-06-25 WO claimed
EP-0946093-A2 FUNGICIDAL COMPOSITIONS BASED ON (N-PHENYLACETYL-N-2,6-XYLYL)METHYL ALANINATE ISAGRO S.p.A. (IT) 1999-10-06 EP disclosed
WO-1998026654-A2 FUNGICIDAL COMPOSITIONS BASED ON (N-PHENYLACETYL-N-2,6-XYLYL)METHYL ALANINATE ISAGRO S.P.A. (IT) 1998-06-25 WO disclosed