SCHEMBL8464950

SCHEMBL8464950

CCCCCCCCSCCCCC(=O)Cl

nearest known ligand 0.75

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 5/20 0.75
ALDH1A1 P00352 4/20 0.75
TP53 P04637 2/20 0.60
CES2 O00748 6/20 0.53
HSD17B10 Q99714 2/20 0.53
GMNN O75496 1/20 0.53
POLB P06746 1/20 0.53
MAPT P10636 1/20 0.53
THRB P10828 1/20 0.53
CYP2C9 P11712 1/20 0.53
BLM P54132 1/20 0.53
CES1 P23141 7/20 0.48
FAAH O00519 4/20 0.47
PLA2G6 O60733 1/20 0.47
PPARG P37231 6/20 0.46
PPARD Q03181 6/20 0.46
PPARA Q07869 6/20 0.46
GPR84 Q9NQS5 5/20 0.46
HDAC11 Q96DB2 5/20 0.46
TLR2 O60603 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7743848 1.00 TSHR (0.75) TSHRALDH1A1TP53CES2HSD17B10
SCHEMBL7749088 1.00 TSHR (0.75) TSHRALDH1A1TP53CES2HSD17B10
SCHEMBL11337171 0.92 TSHR (0.61) TSHRALDH1A1TP53CES2HSD17B10
SCHEMBL9050797 0.92 TSHR (0.61) TSHRALDH1A1TP53CES2HSD17B10
SCHEMBL8624811 0.92 TSHR (0.61) TSHRALDH1A1TP53CES2HSD17B10
SCHEMBL9015601 0.92 TSHR (0.61) TSHRALDH1A1TP53CES2HSD17B10
SCHEMBL9015611 0.92 TSHR (0.61) TSHRALDH1A1TP53CES2HSD17B10
SCHEMBL8467609 0.88 TSHR (0.56) TSHRALDH1A1TP53CES2HSD17B10
SCHEMBL19468445 0.87 TSHR (1.00) TSHRALDH1A1TP53CES2HSD17B10
SCHEMBL19468500 0.87 TSHR (1.00) TSHRALDH1A1TP53CES2HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5981580-A IN WHICH THE CARBOXY-TERMINUS HAS BEEN MODIFIED TO FORM VARIOUS AMIDES, ESTERS, KETONES, ALCOHOLS, ALCOHOL ESTERS AND NITRITES THEREOF, AND ARE USEFUL AS SUBSTRATES FOR N-MYRISTOYLTRANSFERASE (NMT) AND/OR ITS ACYL COENZYME G. D. SEARLE & CO. (US) 1999-11-09 US disclosed
WO-1999050229-A1 FATTY ACID ANALOGS AND PRODRUGS G.D. SEARLE & CO. (US) 1999-10-07 WO disclosed
US-5952377-A SUBSTRATES FOR N-MYRISTOYLTRANSFERASE (NMT) AND/OR ITS ACYL COENZYME, AS ANTI-VIRAL AND ANTI-FUNGAL AGENTS OR PRO-DRUGS; TREATING AIDS, LENTIVIRUSES SUCH AS THE HUMAN IMMUNODEFICIENCY VIRUS G. D. SEARLE & CO. (US) 1999-09-14 US disclosed
US-5929110-A USEFUL AS SUBSTRATES FOR N-MYRISTOYLTRANSFERASE (NMT) AND/OR ITS ACYL COENZYME, AND AS ANTI-VIRAL AND ANTI-FUNGAL AGENTS OR PRO-DRUGS OF SUCH AGENTS G. D. SEARLE & CO. (US) 1999-07-27 US disclosed
US-5859052-A TREATING LENTIVIRUS INFECTIONS, ESPECIALLY HUMAN IMMUNODEFICIENCY VIRUS G. D. SEARLE & CO. (US) 1999-01-12 US disclosed
US-5744631-A Fatty acid analogs and prodrugs G.D. SEARLE & CO. (US) 1998-04-28 US disclosed
US-5719290-A METHYLOXYUNDECYL- OR DECYLOXYETHYL-NITRILE OR TETRAZOLE DERIVATIVES; VIRICIDES G. D. SEARLE & CO. (US) 1998-02-17 US disclosed
US-5672769-A CHEMICAL INTERMEDIATES FOR VIRICIDES, FUNGICIDES G. D. SEARLE & CO. (US) 1997-09-30 US disclosed
US-5670650-A ANTIVIRAL AND ANTIFUNGAL AGENTS G. D. SEARLE & CO. (US) 1997-09-23 US disclosed
US-5599947-A VIRICIDES, FUNGICIDES OR THEIR PRODRUGS G. D. SEARLE & CO. (US) 1997-02-04 US disclosed