Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 7/20 | 0.67 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.52 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.52 |
| ▸ | PDE4A | P27815 | 2/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8465250 | 1.00 | LTB4R (0.67) | LTB4RCYSLTR1CYSLTR2PDE4APDE4B | |
| SCHEMBL8465238 | 1.00 | LTB4R (0.67) | LTB4RCYSLTR1CYSLTR2PDE4APDE4B | |
| SCHEMBL8889256 | 0.86 | LTB4R (0.62) | LTB4RCYSLTR1CYSLTR2 | |
| SCHEMBL8463961 | 0.83 | LTB4R (0.57) | LTB4RCYSLTR1CYSLTR2PDE4APDE4B | |
| SCHEMBL8463969 | 0.83 | LTB4R (0.57) | LTB4RCYSLTR1CYSLTR2PDE4APDE4B | |
| SCHEMBL8463973 | 0.83 | LTB4R (0.57) | LTB4RCYSLTR1CYSLTR2PDE4APDE4B | |
| SCHEMBL8465975 | 0.80 | LTB4R (1.00) | LTB4RCYSLTR1CYSLTR2PDE10AALOX5AP | |
| SCHEMBL8466125 | 0.80 | LTB4R (1.00) | LTB4RCYSLTR1CYSLTR2PDE10AALOX5AP | |
| SCHEMBL8466123 | 0.80 | LTB4R (1.00) | LTB4RCYSLTR1CYSLTR2PDE10AALOX5AP | |
| SCHEMBL8462006 | 0.80 | LTB4R (1.00) | LTB4RCYSLTR1CYSLTR2PDE10AALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5998451-A | LIPOXYGENASE INHIBITORS | PFIZER INC (US) | 1999-12-07 | — | — | US | disclosed |
| EP-0313295-A2 | Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases | PFIZER INC. (US) | 1989-04-26 | — | — | EP | disclosed |