SCHEMBL8465308

SCHEMBL8465308

COCCCCCCCCCCCC(=O)NCCc1ccccc1

nearest known ligand 0.74

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.74
LMNA P02545 1/20 0.74
HDAC3 O15379 3/20 0.69
HDAC1 Q13547 3/20 0.69
HDAC2 Q92769 3/20 0.69
HDAC10 Q969S8 3/20 0.69
HDAC11 Q96DB2 3/20 0.69
HDAC8 Q9BY41 3/20 0.69
HDAC6 Q9UBN7 3/20 0.69
NCOR2 Q9Y618 3/20 0.69
TAAR1 Q96RJ0 1/20 0.66
F13A1 P00488 1/20 0.63
HDAC4 P56524 2/20 0.62
HDAC9 Q9UKV0 2/20 0.62
HPGD P15428 2/20 0.60
MEN1 O00255 2/20 0.60
KMT2A Q03164 2/20 0.60
HDAC7 Q8WUI4 1/20 0.60
HDAC5 Q9UQL6 1/20 0.60
EPHX2 P34913 2/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1231729 0.87 HDAC3 (0.71) KDM4ELMNAHDAC3HDAC1HDAC2
SCHEMBL28301860 0.87 LMNA (0.86) KDM4ELMNAHDAC3HDAC1HDAC2
SCHEMBL8464732 0.85 MEN1 (0.76) KDM4ELMNAHPGDMEN1KMT2A
SCHEMBL1456740 0.84 EPHX2 (0.80) HDAC3HDAC1HDAC2HDAC10HDAC11
SCHEMBL19043177 0.84 EPHX2 (0.80) HDAC3HDAC1HDAC2HDAC10HDAC11
SCHEMBL4183114 0.84 EPHX2 (0.80) HDAC3HDAC1HDAC2HDAC10HDAC11
SCHEMBL30445464 0.84 EPHX2 (0.80) HDAC3HDAC1HDAC2HDAC10HDAC11
SCHEMBL27029534 0.84 EPHX2 (0.80) HDAC3HDAC1HDAC2HDAC10HDAC11
SCHEMBL7436977 0.83 HDAC3 (0.79) LMNAHDAC3HDAC1HDAC2HDAC10
SCHEMBL7441298 0.83 HDAC3 (0.79) LMNAHDAC3HDAC1HDAC2HDAC10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5981580-A IN WHICH THE CARBOXY-TERMINUS HAS BEEN MODIFIED TO FORM VARIOUS AMIDES, ESTERS, KETONES, ALCOHOLS, ALCOHOL ESTERS AND NITRITES THEREOF, AND ARE USEFUL AS SUBSTRATES FOR N-MYRISTOYLTRANSFERASE (NMT) AND/OR ITS ACYL COENZYME G. D. SEARLE & CO. (US) 1999-11-09 US disclosed
WO-1999050229-A1 FATTY ACID ANALOGS AND PRODRUGS G.D. SEARLE & CO. (US) 1999-10-07 WO disclosed
US-5952377-A SUBSTRATES FOR N-MYRISTOYLTRANSFERASE (NMT) AND/OR ITS ACYL COENZYME, AS ANTI-VIRAL AND ANTI-FUNGAL AGENTS OR PRO-DRUGS; TREATING AIDS, LENTIVIRUSES SUCH AS THE HUMAN IMMUNODEFICIENCY VIRUS G. D. SEARLE & CO. (US) 1999-09-14 US disclosed
US-5929110-A USEFUL AS SUBSTRATES FOR N-MYRISTOYLTRANSFERASE (NMT) AND/OR ITS ACYL COENZYME, AND AS ANTI-VIRAL AND ANTI-FUNGAL AGENTS OR PRO-DRUGS OF SUCH AGENTS G. D. SEARLE & CO. (US) 1999-07-27 US disclosed
US-5859052-A TREATING LENTIVIRUS INFECTIONS, ESPECIALLY HUMAN IMMUNODEFICIENCY VIRUS G. D. SEARLE & CO. (US) 1999-01-12 US disclosed
US-5744631-A Fatty acid analogs and prodrugs G.D. SEARLE & CO. (US) 1998-04-28 US disclosed
US-5719290-A METHYLOXYUNDECYL- OR DECYLOXYETHYL-NITRILE OR TETRAZOLE DERIVATIVES; VIRICIDES G. D. SEARLE & CO. (US) 1998-02-17 US disclosed
US-5672769-A CHEMICAL INTERMEDIATES FOR VIRICIDES, FUNGICIDES G. D. SEARLE & CO. (US) 1997-09-30 US disclosed
US-5670650-A ANTIVIRAL AND ANTIFUNGAL AGENTS G. D. SEARLE & CO. (US) 1997-09-23 US disclosed
US-5599947-A VIRICIDES, FUNGICIDES OR THEIR PRODRUGS G. D. SEARLE & CO. (US) 1997-02-04 US disclosed