SCHEMBL8465387

SCHEMBL8465387

CCCCCCCCCCOCCC(=O)Cl

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 4/20 0.61
ALDH1A1 P00352 3/20 0.61
TP53 P04637 1/20 0.54
CES2 O00748 5/20 0.53
MEN1 O00255 2/20 0.52
KMT2A Q03164 2/20 0.52
THRB P10828 1/20 0.52
HTT P42858 1/20 0.52
MAPT P10636 1/20 0.52
NAAA Q02083 1/20 0.45
DGKA P23743 1/20 0.45
CES1 P23141 3/20 0.43
EPHX1 P07099 1/20 0.42
PPARG P37231 3/20 0.41
PPARD Q03181 3/20 0.41
PPARA Q07869 3/20 0.41
GPR84 Q9NQS5 2/20 0.41
HDAC11 Q96DB2 2/20 0.41
TDP1 Q9NUW8 2/20 0.41
SLC22A6 Q4U2R8 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11688123 1.00 TSHR (0.61) TSHRALDH1A1TP53CES2MEN1
SCHEMBL5165951 1.00 TSHR (0.61) TSHRALDH1A1TP53CES2MEN1
SCHEMBL8877230 1.00 TSHR (0.61) TSHRALDH1A1TP53CES2MEN1
SCHEMBL29187635 0.92 ALDH1A1 (0.68) TSHRALDH1A1TP53CES2MEN1
SCHEMBL883376 0.91 ALDH1A1 (0.58) TSHRALDH1A1TP53CES2MEN1
SCHEMBL9502772 0.90 ALDH1A1 (0.65) TSHRALDH1A1TP53CES2MEN1
SCHEMBL17059047 0.89 ALDH1A1 (0.56) TSHRALDH1A1TP53CES2MEN1
SCHEMBL2953187 0.89 ALDH1A1 (0.42) TSHRALDH1A1TP53CES2MEN1
SCHEMBL13986867 0.88 TSHR (0.68) TSHRALDH1A1TP53CES2MEN1
SCHEMBL27272346 0.83 TSHR (0.64) TSHRALDH1A1TP53CES2MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5981580-A IN WHICH THE CARBOXY-TERMINUS HAS BEEN MODIFIED TO FORM VARIOUS AMIDES, ESTERS, KETONES, ALCOHOLS, ALCOHOL ESTERS AND NITRITES THEREOF, AND ARE USEFUL AS SUBSTRATES FOR N-MYRISTOYLTRANSFERASE (NMT) AND/OR ITS ACYL COENZYME G. D. SEARLE & CO. (US) 1999-11-09 US disclosed
WO-1999050229-A1 FATTY ACID ANALOGS AND PRODRUGS G.D. SEARLE & CO. (US) 1999-10-07 WO disclosed
US-5952377-A SUBSTRATES FOR N-MYRISTOYLTRANSFERASE (NMT) AND/OR ITS ACYL COENZYME, AS ANTI-VIRAL AND ANTI-FUNGAL AGENTS OR PRO-DRUGS; TREATING AIDS, LENTIVIRUSES SUCH AS THE HUMAN IMMUNODEFICIENCY VIRUS G. D. SEARLE & CO. (US) 1999-09-14 US disclosed
US-5929110-A USEFUL AS SUBSTRATES FOR N-MYRISTOYLTRANSFERASE (NMT) AND/OR ITS ACYL COENZYME, AND AS ANTI-VIRAL AND ANTI-FUNGAL AGENTS OR PRO-DRUGS OF SUCH AGENTS G. D. SEARLE & CO. (US) 1999-07-27 US disclosed
US-5859052-A TREATING LENTIVIRUS INFECTIONS, ESPECIALLY HUMAN IMMUNODEFICIENCY VIRUS G. D. SEARLE & CO. (US) 1999-01-12 US disclosed