Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 19/20 | 0.72 |
| ▸ | LTB4R2 | Q9NPC1 | 19/20 | 0.72 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8465503 | 1.00 | LTB4R (0.72) | LTB4RLTB4R2CYP19A1 | |
| SCHEMBL8465505 | 1.00 | LTB4R (0.72) | LTB4RLTB4R2CYP19A1 | |
| SCHEMBL8462504 | 0.86 | LTB4R (0.53) | LTB4RLTB4R2CYP19A1 | |
| SCHEMBL8462502 | 0.86 | LTB4R (0.53) | LTB4RLTB4R2CYP19A1 | |
| SCHEMBL8462505 | 0.86 | LTB4R (0.53) | LTB4RLTB4R2CYP19A1 | |
| SCHEMBL8888895 | 0.86 | LTB4R (0.53) | LTB4RLTB4R2CYP19A1 | |
| SCHEMBL9180322 | 0.85 | LTB4R (0.66) | LTB4RLTB4R2 | |
| SCHEMBL8888366 | 0.85 | LTB4R (0.66) | LTB4RLTB4R2 | |
| SCHEMBL9178762 | 0.85 | LTB4R (0.66) | LTB4RLTB4R2 | |
| SCHEMBL8888363 | 0.85 | LTB4R (0.66) | LTB4RLTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5998451-A | LIPOXYGENASE INHIBITORS | PFIZER INC (US) | 1999-12-07 | — | — | US | disclosed |
| EP-0313295-B1 | SUBSTITUTED TETRALINS, CHROMANS AND RELATED COMPOUNDS IN THE TREATMENT OF ASTHMA, ARTHRITIS AND RELATED DISEASES | PFIZER INC. (US) | 1993-07-28 | — | — | EP | disclosed |
| US-5059609-A | Lipoxygenase inhibitors; leukotriene receptor blockers; psoriasis; antiulcer agents and myocardial infarctions | PFIZER INC. (US) | 1991-10-22 | — | — | US | disclosed |
| EP-0313295-A2 | Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases | PFIZER INC. (US) | 1989-04-26 | — | — | EP | disclosed |