Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 10/20 | 0.49 |
| ▸ | MAOA | P21397 | 5/20 | 0.49 |
| ▸ | BCHE | P06276 | 3/20 | 0.49 |
| ▸ | ACHE | P22303 | 3/20 | 0.49 |
| ▸ | APP | P05067 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | MIF | P14174 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8465615 | 1.00 | MAOB (0.49) | MAOBMAOABCHEACHEAPP | |
| SCHEMBL9661085 | 0.91 | MAOB (0.50) | MAOBMAOABCHEACHEAPP | |
| SCHEMBL9661080 | 0.91 | MAOB (0.50) | MAOBMAOABCHEACHEAPP | |
| SCHEMBL8462121 | 0.86 | MAPT (0.53) | MAOBAPPMEN1KMT2AATM | |
| SCHEMBL8462118 | 0.86 | MAPT (0.53) | MAOBAPPMEN1KMT2AATM | |
| SCHEMBL8889671 | 0.85 | MAOB (0.48) | MAOBMAOAMEN1KMT2AATM | |
| SCHEMBL8889666 | 0.85 | MAOB (0.48) | MAOBMAOAMEN1KMT2AATM | |
| SCHEMBL3321946 | 0.79 | MAOB (0.56) | MAOBMAOABCHEACHEAPP | |
| SCHEMBL3321947 | 0.79 | MAOB (0.56) | MAOBMAOABCHEACHEAPP | |
| SCHEMBL8466048 | 0.79 | MAPT (0.66) | MAOBAPPMEN1KMT2AMIF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5998451-A | LIPOXYGENASE INHIBITORS | PFIZER INC (US) | 1999-12-07 | — | — | US | disclosed |
| US-5298512-A | Substituted chromans and their use in the treatment of asthma, arthritis and related diseases | PFIZER INC. (US) | 1994-03-29 | — | — | US | disclosed |
| EP-0391625-B1 | Substituted chromans in the treatment of asthma, arthritis and related diseases | PFIZER (US) | 1994-01-26 | — | — | EP | disclosed |
| EP-0313295-B1 | SUBSTITUTED TETRALINS, CHROMANS AND RELATED COMPOUNDS IN THE TREATMENT OF ASTHMA, ARTHRITIS AND RELATED DISEASES | PFIZER INC. (US) | 1993-07-28 | — | — | EP | disclosed |
| US-5059609-A | Lipoxygenase inhibitors; leukotriene receptor blockers; psoriasis; antiulcer agents and myocardial infarctions | PFIZER INC. (US) | 1991-10-22 | — | — | US | disclosed |
| WO-1990012010-A1 | SUBSTITUTED CHROMANS IN THE TREATMENT OF ASTHMA, ARTHRITIS AND RELATED DISEASES | PFIZER INC. (US) | 1990-10-18 | — | — | WO | disclosed |
| EP-0391625-A1 | Substituted chromans in the treatment of asthma, arthritis and related diseases | PFIZER INC. (US) | 1990-10-10 | — | — | EP | disclosed |
| EP-0313295-A2 | Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases | PFIZER INC. (US) | 1989-04-26 | — | — | EP | disclosed |