Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.55 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.55 |
| ▸ | LTB4R | Q15722 | 14/20 | 0.53 |
| ▸ | LTB4R2 | Q9NPC1 | 5/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8465586 | 1.00 | CYSLTR1 (0.55) | CYSLTR1CYSLTR2LTB4RLTB4R2USP2 | |
| SCHEMBL8465588 | 1.00 | CYSLTR1 (0.55) | CYSLTR1CYSLTR2LTB4RLTB4R2USP2 | |
| SCHEMBL8465579 | 1.00 | CYSLTR1 (0.55) | CYSLTR1CYSLTR2LTB4RLTB4R2USP2 | |
| SCHEMBL8462733 | 0.91 | CYSLTR1 (0.64) | CYSLTR1CYSLTR2LTB4RLTB4R2 | |
| SCHEMBL8462737 | 0.91 | CYSLTR1 (0.64) | CYSLTR1CYSLTR2LTB4RLTB4R2 | |
| SCHEMBL8462745 | 0.91 | CYSLTR1 (0.64) | CYSLTR1CYSLTR2LTB4RLTB4R2 | |
| SCHEMBL8466039 | 0.87 | LTB4R (0.69) | CYSLTR1CYSLTR2LTB4R | |
| SCHEMBL8464461 | 0.87 | LTB4R (0.69) | CYSLTR1CYSLTR2LTB4R | |
| SCHEMBL8524172 | 0.87 | LTB4R (0.69) | CYSLTR1CYSLTR2LTB4R | |
| SCHEMBL8524170 | 0.87 | LTB4R (0.69) | CYSLTR1CYSLTR2LTB4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5998451-A | LIPOXYGENASE INHIBITORS | PFIZER INC (US) | 1999-12-07 | — | — | US | disclosed |
| US-5059609-A | Lipoxygenase inhibitors; leukotriene receptor blockers; psoriasis; antiulcer agents and myocardial infarctions | PFIZER INC. (US) | 1991-10-22 | — | — | US | disclosed |
| EP-0313295-A2 | Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases | PFIZER INC. (US) | 1989-04-26 | — | — | EP | disclosed |