Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 5/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.73 |
| ▸ | MAPT | P10636 | 3/20 | 0.73 |
| ▸ | HPGD | P15428 | 2/20 | 0.73 |
| ▸ | ATM | Q13315 | 2/20 | 0.73 |
| ▸ | MAOB | P27338 | 8/20 | 0.70 |
| ▸ | TP53 | P04637 | 2/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.59 |
| ▸ | MIF | P14174 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8465775 | 1.00 | APP (0.79) | APPALDH1A1MAPTHPGDATM | |
| SCHEMBL5725497 | 0.91 | MAPT (0.77) | APPALDH1A1MAPTHPGDATM | |
| SCHEMBL5725448 | 0.83 | MAOB (0.67) | APPALDH1A1MAPTHPGDATM | |
| SCHEMBL5724831 | 0.83 | MAOB (0.67) | APPALDH1A1MAPTHPGDATM | |
| SCHEMBL25035409 | 0.83 | CXCL12 (0.80) | APPALDH1A1MAPTHPGDATM | |
| SCHEMBL30274371 | 0.83 | CXCL12 (0.80) | APPALDH1A1MAPTHPGDATM | |
| SCHEMBL14160665 | 0.83 | MAPT (0.82) | APPALDH1A1MAPTHPGDATM | |
| SCHEMBL25035376 | 0.82 | APP (0.77) | APPALDH1A1MAPTHPGDATM | |
| SCHEMBL4732781 | 0.82 | MAOB (0.76) | APPALDH1A1MAPTHPGDATM | |
| SCHEMBL31567962 | 0.82 | APP (0.78) | APPALDH1A1MAPTHPGDATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5998451-A | LIPOXYGENASE INHIBITORS | PFIZER INC (US) | 1999-12-07 | — | — | US | disclosed |
| EP-0313295-B1 | SUBSTITUTED TETRALINS, CHROMANS AND RELATED COMPOUNDS IN THE TREATMENT OF ASTHMA, ARTHRITIS AND RELATED DISEASES | PFIZER INC. (US) | 1993-07-28 | — | — | EP | disclosed |
| US-5059609-A | Lipoxygenase inhibitors; leukotriene receptor blockers; psoriasis; antiulcer agents and myocardial infarctions | PFIZER INC. (US) | 1991-10-22 | — | — | US | disclosed |
| EP-0313295-A2 | Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases | PFIZER INC. (US) | 1989-04-26 | — | — | EP | disclosed |