Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 11/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | LPAR2 | Q9HBW0 | 3/20 | 0.39 |
| ▸ | AVPR1A | P37288 | 4/20 | 0.38 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6571491 | 0.82 | AVPR1A (0.42) | LPAR1AVPR1AAVPR1B | |
| SCHEMBL6571483 | 0.82 | AVPR1A (0.42) | LPAR1AVPR1AAVPR1B | |
| SCHEMBL6570407 | 0.82 | LPAR1 (0.46) | LPAR1HTTLPAR2MAPK1L3MBTL1 | |
| SCHEMBL1492154 | 0.80 | LPAR1 (0.39) | LPAR1KDM4EHTTLPAR2AVPR1A | |
| SCHEMBL6472382 | 0.80 | LPAR1 (0.39) | LPAR1KDM4EHTTLPAR2AVPR1A | |
| SCHEMBL6573735 | 0.80 | KDM4E (0.42) | LPAR1KDM4EGAAHTTMAPK1 | |
| SCHEMBL6573744 | 0.80 | KDM4E (0.42) | LPAR1KDM4EGAAHTTMAPK1 | |
| Timcodar SCHEMBL1492143 | 0.77 | L3MBTL1 (0.37) | LPAR1HTTMAPK1L3MBTL1ALDH1A1 | |
| SCHEMBL6570448 | 0.77 | L3MBTL1 (0.37) | LPAR1HTTMAPK1L3MBTL1ALDH1A1 | |
| Timcodar SCHEMBL3673444 | 0.77 | L3MBTL1 (0.37) | LPAR1HTTMAPK1L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946190-A1 | METHODS AND COMPOSITIONS FOR STIMULATING NEURITE GROWTH USING COMPOUNDS WITH AFFINITY FOR FKBP12 IN COMBINATION WITH NEUROTROPHIC FACTORS | Vertex Pharmaceuticals Incorporated (US) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998020891-A1 | METHODS AND COMPOSITIONS FOR STIMULATING NEURITE GROWTH USING COMPOUNDS WITH AFFINITY FOR FKBP12 IN COMBINATION WITH NEUROTROPHIC FACTORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 1998-05-22 | — | — | WO | disclosed |