Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 4/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | DNM1 | Q05193 | 3/20 | 0.54 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.48 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.48 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.48 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | GGPS1 | O95749 | 4/20 | 0.44 |
| ▸ | FDPS | P14324 | 1/20 | 0.44 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HBB | P68871 | 1/20 | 0.42 |
| ▸ | KDM5A | P29375 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methylamine SCHEMBL6265466 | 0.93 | TSHR (0.59) | TSHRALDH1A1DNM1S1PR2S1PR1 | |
| SCHEMBL7265266 | 0.93 | TSHR (0.57) | TSHRALDH1A1DNM1S1PR2S1PR1 | |
| Methylamine SCHEMBL2024601 | 0.91 | TSHR (0.56) | TSHRALDH1A1DNM1S1PR2S1PR1 | |
| Methylamine SCHEMBL6303494 | 0.91 | TSHR (0.56) | TSHRALDH1A1DNM1S1PR2S1PR1 | |
| SCHEMBL10957981 | 0.88 | MAPT (0.60) | TSHRALDH1A1DNM1S1PR2S1PR1 | |
| SCHEMBL26685916 | 0.88 | MAPT (0.60) | TSHRALDH1A1DNM1S1PR2S1PR1 | |
| SCHEMBL11825151 | 0.88 | TSHR (0.50) | TSHRALDH1A1DNM1S1PR2S1PR1 | |
| SCHEMBL31325281 | 0.87 | MAPT (0.56) | TSHRALDH1A1DNM1S1PR2S1PR1 | |
| Bromide SCHEMBL5531256 | 0.87 | DNM1 (0.68) | TSHRDNM1S1PR2S1PR1S1PR3 | |
| Bromide SCHEMBL3059787 | 0.87 | DNM1 (0.68) | TSHRDNM1S1PR2S1PR1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5969090-A | QUATERNIZED CROSSLINKED HYDROCARBON AMINE POLYMER | GELTEX PHARMACEUTICALS, INC. (US) | 1999-10-19 | — | — | US | disclosed |
| US-5900475-A | MODIFIED POLYALLYLAMINE; ANTICHOLESTEROL AGENT | GELTEX PHARMACEUTICALS, INC. (US) | 1999-05-04 | — | — | US | disclosed |
| EP-0830390-A1 | HYDROPHOBIC HETEROATOM-CONTAINING SEQUESTRANT FOR CHOLESTEROL DEPLETION | GELTEX PHARMACEUTICALS, INC. (US) | 1998-03-25 | — | — | EP | disclosed |
| WO-1996039449-A1 | HYDROPHOBIC HETEROATOM-CONTAINING SEQUESTRANT FOR CHOLESTEROL DEPLETION | GELTEX PHARMACEUTICALS, INC. (US) | 1996-12-12 | — | — | WO | disclosed |