Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA3 | P07451 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA6 | P23280 | 1/20 | 0.41 |
| ▸ | CA5A | P35218 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19975025 | 0.83 | LMNA (0.42) | LMNACA12CA1CA2CA3 | |
| SCHEMBL15106072 | 0.81 | LMNA (0.44) | LMNACA12CA1CA2CA3 | |
| SCHEMBL8331968 | 0.81 | LMNA (0.44) | LMNACA12CA1CA2CA3 | |
| SCHEMBL15113459 | 0.81 | LMNA (0.44) | LMNACA12CA1CA2CA3 | |
| SCHEMBL22648649 | 0.80 | LMNA (0.51) | LMNACA12CA1CA2CA3 | |
| SCHEMBL15116502 | 0.80 | LMNA (0.41) | LMNACA12CA1CA2CA3 | |
| SCHEMBL22151991 | 0.79 | LMNA (0.43) | LMNACA12CA1CA2CA3 | |
| SCHEMBL28977958 | 0.78 | LMNA (0.47) | LMNACA12CA1CA2CA3 | |
| SCHEMBL19388177 | 0.77 | ATM (0.44) | LMNAALDH1A1MEN1KMT2ACYP2C9 | |
| SCHEMBL3725271 | 0.76 | LMNA (0.49) | LMNACA12CA1CA2CA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0730467-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 1999-01-13 | — | — | EP | disclosed |
| EP-0730467-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO. INC. (US) | 1996-09-11 | — | — | EP | disclosed |
| US-5468733-A | FOR TREATING CANCER | MERCK & CO., INC. (US) | 1995-11-21 | — | — | US | disclosed |
| WO-1995009000-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1995-04-06 | — | — | WO | disclosed |