Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.49 |
| ▸ | MEN1 | O00255 | 6/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2774863 | 0.90 | KMT2A (0.52) | KMT2AMEN1GAALMNAMAPT | |
| SCHEMBL2774862 | 0.90 | KMT2A (0.52) | KMT2AMEN1GAALMNAMAPT | |
| SCHEMBL2774860 | 0.90 | KMT2A (0.52) | KMT2AMEN1GAALMNAMAPT | |
| SCHEMBL2775584 | 0.87 | MEN1 (0.53) | KMT2AMEN1GAALMNAMAPT | |
| SCHEMBL2775582 | 0.87 | MEN1 (0.53) | KMT2AMEN1GAALMNAMAPT | |
| SCHEMBL2775579 | 0.87 | MEN1 (0.53) | KMT2AMEN1GAALMNAMAPT | |
| SCHEMBL2777232 | 0.78 | TMEM97 (0.43) | KMT2AMEN1GAALMNAMAPT | |
| SCHEMBL2777229 | 0.78 | TMEM97 (0.43) | KMT2AMEN1GAALMNAMAPT | |
| SCHEMBL2777224 | 0.78 | TMEM97 (0.43) | KMT2AMEN1GAALMNAMAPT | |
| SCHEMBL2777427 | 0.76 | MEN1 (0.43) | KMT2AMEN1GAALMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2184276-A1 | Process to prepare new substituted 1H-Benzo(d) imidazol-2(3h)-Ones, New intermediates and their use as bace 1 inhibitors | UNIVERSITE PAUL CEZANNE AIX-MARSEILLE III (FR) | 2010-05-12 | — | — | EP | disclosed |