Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.44 |
| ▸ | NPC1 | O15118 | 6/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.44 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 3/20 | 0.41 |
| ▸ | MMP2 | P08253 | 3/20 | 0.41 |
| ▸ | MMP9 | P14780 | 3/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | STAT1 | P42224 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL846919 | 1.00 | RAB9A (0.44) | RAB9ANPC1SMN1; SMN2LMNATRPV1 | |
| SCHEMBL846661 | 0.90 | NPC1 (0.56) | RAB9ANPC1SMN1; SMN2LMNATRPV1 | |
| SCHEMBL846660 | 0.90 | NPC1 (0.56) | RAB9ANPC1SMN1; SMN2LMNATRPV1 | |
| SCHEMBL848119 | 0.79 | TRPV1 (0.45) | RAB9ANPC1SMN1; SMN2LMNATRPV1 | |
| SCHEMBL848118 | 0.79 | TRPV1 (0.45) | RAB9ANPC1SMN1; SMN2LMNATRPV1 | |
| SCHEMBL846459 | 0.78 | NPC1 (0.57) | RAB9ANPC1SMN1; SMN2LMNATRPV1 | |
| SCHEMBL846755 | 0.78 | NPC1 (0.57) | RAB9ANPC1SMN1; SMN2LMNATRPV1 | |
| SCHEMBL846559 | 0.78 | TRPV1 (0.54) | RAB9ANPC1SMN1; SMN2LMNATRPV1 | |
| SCHEMBL846558 | 0.78 | TRPV1 (0.54) | RAB9ANPC1SMN1; SMN2LMNATRPV1 | |
| SCHEMBL846230 | 0.76 | MAPT (0.56) | RAB9ANPC1SMN1; SMN2LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603883-B1 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-28 | — | — | EP | disclosed |
| EP-2308848-A1 | Quinoline-derived amide modulators of vanilloid VR1 receptor | Janssen Pharmaceutica NV (BE) | 2011-04-13 | — | — | EP | disclosed |