Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | NPY1R | P25929 | 1/20 | 0.36 |
| ▸ | NPY2R | P49146 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | SYK | P43405 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL847744 | 0.80 | STAT6 (0.39) | MAPK8SYKEGFRZAP70STAT6 | |
| SCHEMBL27800295 | 0.79 | MAPT (0.42) | MAPTSMN1; SMN2MEN1GAAKMT2A | |
| SCHEMBL14617173 | 0.79 | GAA (0.46) | MAPTSMN1; SMN2MEN1GAAKMT2A | |
| SCHEMBL848924 | 0.77 | CYP1A2 (0.44) | ALDH1A1CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL846971 | 0.77 | STAT6 (0.38) | SMN1; SMN2MAPK8SYKEGFRZAP70 | |
| SCHEMBL846959 | 0.76 | FFAR1 (0.40) | SMN1; SMN2KMT2AMAPK8ALDH1A1SYK | |
| SCHEMBL8171612 | 0.75 | DHODH (0.57) | MAPTSMN1; SMN2MEN1GAAKMT2A | |
| SCHEMBL847717 | 0.74 | KMT2A (0.42) | MAPTSMN1; SMN2MEN1GAAKMT2A | |
| SCHEMBL846982 | 0.74 | MAPT (0.44) | MAPTSMN1; SMN2MEN1GAAKMT2A | |
| SCHEMBL848421 | 0.73 | FAAH (0.41) | MEN1KMT2AHPGDNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2148862-B1 | DIHYDROQUINONE AND DIHYDRONAPHTHRIDINE INHIBITORS OF JNK | HOFFMANN LA ROCHE (CH) | 2012-03-28 | — | — | EP | disclosed |