SCHEMBL8469731

SCHEMBL8469731

CCC(=CC1=C(C)CCCC1(C)C)C(C)=C(Cl)C(=O)O

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HAO1 Q9UJM8 1/20 0.47
CYP1A2 P05177 2/20 0.47
RARA P10276 6/20 0.42
RARB P10826 6/20 0.42
RARG P13631 6/20 0.42
ALDH1A1 P00352 8/20 0.41
RXRA P19793 7/20 0.41
MAPT P10636 5/20 0.41
CYP3A4 P08684 5/20 0.41
PTGS1 P23219 4/20 0.41
RXRB P28702 3/20 0.41
RXRG P48443 3/20 0.41
RORC P51449 2/20 0.41
ADORA3 P0DMS8 2/20 0.41
MAPK1 P28482 2/20 0.41
HTR2B P41595 2/20 0.41
BLM P54132 2/20 0.41
HIF1A Q16665 2/20 0.41
DRD3 P35462 2/20 0.41
LMNA P02545 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14430255 0.83 CYP1A2 (0.51) HAO1CYP1A2RARARARBRARG
SCHEMBL30358271 0.74 CYP1A2 (0.51) HAO1CYP1A2RARARARBRARG
SCHEMBL8474784 0.74 CYP1A2 (0.55) HAO1CYP1A2RARARARBRARG
SCHEMBL1472109 0.70 CYP1A2 (0.57) HAO1CYP1A2RARARARBRARG
SCHEMBL3307322 0.70 CYP1A2 (0.57) HAO1CYP1A2RARARARBRARG
SCHEMBL1472108 0.70 CYP1A2 (0.57) HAO1CYP1A2RARARARBRARG
SCHEMBL10618596 0.68 ALDH1A1 (0.71) CYP1A2RARARARBRARGALDH1A1
SCHEMBL10620486 0.68 ALDH1A1 (0.71) CYP1A2RARARARBRARGALDH1A1
SCHEMBL1404273 0.67 HAO1 (0.72) HAO1CYP1A2RARARARBRARG
SCHEMBL2130233 0.67 HAO1 (0.72) HAO1CYP1A2RARARARBRARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5986131-A UNSATURATED CARBOXYLIC ACID DERIVATIVES AS LIGANDS AND RETINOIC ACID RECEPTORS HOFFMANN-LA ROCHE INC. (US) 1999-11-16 US disclosed
EP-0728742-B1 Novel retinoids HOFFMANN LA ROCHE (CH) 1999-10-20 EP disclosed
EP-0728742-A2 Novel retinoids F. HOFFMANN-LA ROCHE AG (CH) 1996-08-28 EP disclosed