Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 5/20 | 0.38 |
| ▸ | HTR6 | P50406 | 5/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | CHUK | O15111 | 4/20 | 0.35 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | TTK | P33981 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8469870 | 0.83 | BRD4 (0.38) | BRD4HTR6DRD2HTR2AHTR7 | |
| SCHEMBL3348977 | 0.80 | HTR6 (0.48) | BRD4HTR6DRD2HTR2AHTR7 | |
| SCHEMBL8443781 | 0.80 | BRD4 (0.44) | BRD4HTR6DRD2HTR2AHTR7 | |
| SCHEMBL2752527 | 0.78 | HTR6 (0.41) | BRD4HTR6DRD2HTR2AHTR7 | |
| SCHEMBL8443783 | 0.78 | BCL2L1 (0.41) | BRD4HTR6DRD2HTR2AHTR7 | |
| SCHEMBL8480893 | 0.77 | BRD4 (0.38) | BRD4HTR6DRD2HTR2AHTR7 | |
| SCHEMBL13745818 | 0.77 | KDR (0.51) | BRD4HTR6DRD2HTR2AHTR7 | |
| SCHEMBL3346622 | 0.76 | BRD4 (0.36) | BRD4HTR6DRD2HTR2AHTR7 | |
| SCHEMBL13746286 | 0.76 | AAK1 (0.50) | BRD4PTPN11ROCK2 | |
| SCHEMBL3348822 | 0.76 | HTR6 (0.40) | BRD4HTR6DRD2HTR2AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1749829-B1 | JNK inhibitors | EISAI R&D MAN CO LTD (JP) | 2010-11-03 | — | — | EP | disclosed |