SCHEMBL8470657

SCHEMBL8470657

CC/C=C\CC1CCC(c2ccc(C(F)(F)Oc3ccc(C#N)c(F)c3)cc2)CC1

nearest known ligand 0.34

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
TRPV4 Q9HBA0 5/20 0.34
TRPC3 Q13507 1/20 0.34
TRPC6 Q9Y210 1/20 0.34
KDM1A O60341 1/20 0.31
AOC3 Q16853 1/20 0.30
EGLN2 Q96KS0 1/20 0.30
CYP11B1 P15538 1/20 0.30
CYP11B2 P19099 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7735143 1.00 TRPV4 (0.34) TRPV4TRPC3TRPC6KDM1AAOC3
SCHEMBL7735138 1.00 TRPV4 (0.34) TRPV4TRPC3TRPC6KDM1AAOC3
SCHEMBL7735135 1.00 TRPV4 (0.34) TRPV4TRPC3TRPC6KDM1AAOC3
SCHEMBL7735136 1.00 TRPV4 (0.34) TRPV4TRPC3TRPC6KDM1AAOC3
SCHEMBL7735386 0.91 TRPC3 (0.36) TRPV4TRPC3TRPC6KDM1AAOC3
SCHEMBL8475052 0.91 TRPC3 (0.36) TRPV4TRPC3TRPC6KDM1AAOC3
SCHEMBL7735389 0.91 TRPC3 (0.36) TRPV4TRPC3TRPC6KDM1AAOC3
SCHEMBL7735388 0.91 TRPC3 (0.36) TRPV4TRPC3TRPC6KDM1AAOC3
SCHEMBL7735383 0.91 TRPC3 (0.36) TRPV4TRPC3TRPC6KDM1AAOC3
SCHEMBL7730524 0.90 TRPC3 (0.36) TRPV4TRPC3TRPC6KDM1AAOC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5858270-A Difluorooxymethane derivative and liquid crystal composition CHISSO CORPORATION (JP) 1999-01-12 US disclosed