Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | LARS1 | Q9P2J5 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 5/20 | 0.43 |
| ▸ | DRD3 | P35462 | 5/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.43 |
| ▸ | DRD4 | P21917 | 2/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8472760 | 0.84 | LTA4H (0.44) | LTA4HLARS1HDAC1GRIN1GRIN2B | |
| SCHEMBL8473537 | 0.78 | PTPN1 (0.59) | HRH3 | |
| SCHEMBL6753874 | 0.78 | LARS1 (0.72) | LTA4HLARS1HDAC1DRD2DRD3 | |
| SCHEMBL13898790 | 0.78 | LARS1 (0.72) | LARS1DRD2KCNH2HRH3CYP2D6 | |
| SCHEMBL8474531 | 0.77 | HDAC1 (0.47) | LTA4HLARS1HDAC1GRIN1GRIN2B | |
| SCHEMBL14393522 | 0.75 | HRH3 (0.55) | HRH3HRH1 | |
| SCHEMBL7275892 | 0.74 | GRIN1 (0.44) | GRIN1GRIN2BDRD2DRD3KCNH2 | |
| SCHEMBL7273056 | 0.74 | PRMT5 (0.51) | HDAC1DRD2DRD3KCNH2DRD4 | |
| SCHEMBL6219605 | 0.74 | HDAC1 (0.57) | HDAC1DRD2DRD3KCNH2NOX4 | |
| SCHEMBL8470488 | 0.74 | HDAC1 (0.57) | HDAC1DRD2DRD3KCNH2NOX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5990139-A | 2,5-DIOXO-4-(PYRIDYL OR PHENYL-(N-HETEROCYCLE(C4N,C3N2))-ALKYLENOXY-(1,4-PHENYLENE) -)THIADIAZOLIDINES; ANTIDIABETIC AND -LIPEMIC AGENTS; SIDE EFFECT REDUCTION | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 1999-11-23 | — | — | US | disclosed |