Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 2/20 | 0.51 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.49 |
| ▸ | PPARA | Q07869 | 4/20 | 0.46 |
| ▸ | PPARG | P37231 | 3/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | MME | P08473 | 2/20 | 0.45 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | RXRB | P28702 | 1/20 | 0.44 |
| ▸ | RXRG | P48443 | 1/20 | 0.44 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3470119 | 0.84 | PNMT (0.56) | PNMTCTBP2PPARAPPARGMDM2 | |
| SCHEMBL3347144 | 0.82 | KDM6B (0.56) | PNMTCTBP2MMEMEN1ALDH1A1 | |
| SCHEMBL8592637 | 0.82 | KDM6B (0.56) | PNMTCTBP2MMEMEN1ALDH1A1 | |
| SCHEMBL7626979 | 0.81 | PNMT (0.53) | PNMTCTBP2PPARAPPARGMEN1 | |
| SCHEMBL1635772 | 0.81 | MME (0.46) | MME | |
| SCHEMBL9659004 | 0.80 | PPARG (0.56) | PPARAPPARGMME | |
| SCHEMBL42994 | 0.79 | SLC7A5 (0.65) | PNMT | |
| SCHEMBL298829 | 0.79 | SLC7A5 (0.65) | PNMT | |
| SCHEMBL21149890 | 0.79 | CTBP2 (0.47) | CTBP2PPARAPPARGCNR1MME | |
| SCHEMBL31324842 | 0.79 | PNMT (0.61) | PNMTCTBP2PPARAPPARGMME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5886016-A | ANTIINFLAMMATORY AGENT WITH MINIMAL SIDE EFFECTS FOR TREATING ARTHRITIS | G.D. SEARLE & CO. (US) | 1999-03-23 | — | — | US | disclosed |
| US-5670532-A | Pyrazolyl derivatives for the treatment of inflammation | G. D. SEARLE & CO. (US) | 1997-09-23 | — | — | US | disclosed |
| US-5565482-A | ANTIINFLAMMATORY AGENTS, ANTIARTHRITIC AGENTS | G.D. SEARLE & CO. (US) | 1996-10-15 | — | — | US | disclosed |
| US-5547975-A | ANTIARTHRIC AGENTS, ANALGESICS AND ANTIPYRETICS; INHIBITORS OF CYCLOOXYGENASE II; SIDE EFFECT REDUCTION | G.D. SEARLE & CO. | 1996-08-20 | — | — | US | disclosed |
| WO-1996009304-A1 | BENZOPYRANOPYRAZOLYL DERIVATIVES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-03-28 | — | — | WO | disclosed |