SCHEMBL8470799

SCHEMBL8470799

c1ccc(N2CCN(CCC3CCC(Nc4ncccn4)CC3)CC2)nc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 19/20 1.00
DRD3 P35462 17/20 1.00
DRD4 P21917 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8470803 1.00 DRD2 (1.00) DRD2DRD3DRD4
Hydrochloric Acid SCHEMBL8472401 0.99 DRD2 (0.98) DRD2DRD3DRD4
Hydrochloric Acid SCHEMBL8472405 0.99 DRD2 (0.98) DRD2DRD3DRD4
SCHEMBL8473283 0.87 DRD2 (1.00) DRD2DRD3
SCHEMBL8473280 0.87 DRD2 (1.00) DRD2DRD3
SCHEMBL8472397 0.86 DRD2 (1.00) DRD2DRD3
Hydrochloric Acid SCHEMBL8470983 0.86 DRD2 (0.98) DRD2DRD3
Hydrochloric Acid SCHEMBL8470975 0.86 DRD2 (0.98) DRD2DRD3
SCHEMBL8470842 0.85 DRD2 (1.00) DRD2DRD3
SCHEMBL8470836 0.85 DRD2 (1.00) DRD2DRD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5977110-A Substituted cyclohexylamines as central nervous systems agents WARNER-LAMBERT COMPANY (US) 1999-11-02 US claimed
WO-1997011070-A1 SUBSTITUTED CYCLOHEXYLAMINES AS CENTRAL NERVOUS SYSTEM AGENTS WARNER-LAMBERT COMPANY (US) 1997-03-27 WO claimed
US-5977110-A Substituted cyclohexylamines as central nervous systems agents WARNER-LAMBERT COMPANY (US) 1999-11-02 US disclosed
WO-1997011070-A1 SUBSTITUTED CYCLOHEXYLAMINES AS CENTRAL NERVOUS SYSTEM AGENTS WARNER-LAMBERT COMPANY (US) 1997-03-27 WO disclosed