Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.56 |
| ▸ | DRD2 | P14416 | 8/20 | 0.51 |
| ▸ | DRD3 | P35462 | 8/20 | 0.51 |
| ▸ | CYP1A1 | P04798 | 5/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | DPP4 | P27487 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.47 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6220245 | 0.85 | HDAC1 (0.56) | HDAC1DRD2DRD3CYP1A1PKM | |
| SCHEMBL14734293 | 0.83 | HDAC1 (0.56) | HDAC1DRD2DRD3CYP1A1PKM | |
| SCHEMBL27968105 | 0.82 | HTR2C (0.55) | DRD2DRD3CYP1A1DPP4KCNH2 | |
| SCHEMBL3714292 | 0.82 | DRD2 (0.61) | HDAC1DRD2DRD3CYP1A1PKM | |
| SCHEMBL2199747 | 0.81 | HDAC1 (0.49) | HDAC1DRD2DRD3CYP1A1PKM | |
| SCHEMBL17080505 | 0.80 | DRD2 (0.48) | HDAC1DRD2DRD3CYP1A1KCNH2 | |
| SCHEMBL17080578 | 0.80 | DRD2 (0.48) | HDAC1DRD2DRD3CYP1A1KCNH2 | |
| SCHEMBL10498393 | 0.80 | CYP1A1 (0.64) | HDAC1DRD2DRD3CYP1A1S1PR1 | |
| SCHEMBL5659037 | 0.80 | DRD2 (0.65) | HDAC1DRD2DRD3KCNH2RAB9A | |
| SCHEMBL27734214 | 0.79 | HDAC1 (0.53) | HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5990139-A | 2,5-DIOXO-4-(PYRIDYL OR PHENYL-(N-HETEROCYCLE(C4N,C3N2))-ALKYLENOXY-(1,4-PHENYLENE) -)THIADIAZOLIDINES; ANTIDIABETIC AND -LIPEMIC AGENTS; SIDE EFFECT REDUCTION | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 1999-11-23 | — | — | US | disclosed |