Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 19/20 | 0.78 |
| ▸ | HTR2A | P28223 | 16/20 | 0.78 |
| ▸ | HTR2B | P41595 | 9/20 | 0.78 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.78 |
| ▸ | MEN1 | O00255 | 1/20 | 0.78 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.78 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.78 |
| ▸ | MAPT | P10636 | 1/20 | 0.78 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.78 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.78 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.54 |
| ▸ | RELA | Q04206 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7082041 | 0.91 | HTR2C (0.68) | HTR2CHTR2AHTR2BCYP1A2MEN1 | |
| SCHEMBL7078072 | 0.90 | HTR2C (0.71) | HTR2CHTR2AHTR2BCYP1A2MEN1 | |
| SCHEMBL24525687 | 0.89 | HTR2C (0.79) | HTR2CHTR2AHTR2BCYP1A2MEN1 | |
| SCHEMBL29766909 | 0.88 | HTR2C (1.00) | HTR2CHTR2AHTR2BCYP1A2MEN1 | |
| SCHEMBL8431394 | 0.88 | HTR2C (1.00) | HTR2CHTR2AHTR2BCYP1A2MEN1 | |
| SCHEMBL8474495 | 0.88 | HTR2C (0.67) | HTR2CHTR2AHTR2BCYP1A2MEN1 | |
| SCHEMBL8476174 | 0.87 | HTR2C (0.70) | HTR2CHTR2AHTR2BCYP1A2MEN1 | |
| SCHEMBL7078879 | 0.87 | HTR2C (0.69) | HTR2CHTR2AHTR2BCYP1A2MEN1 | |
| SCHEMBL7038595 | 0.87 | HTR2C (0.76) | HTR2CHTR2AHTR2BCYP1A2MEN1 | |
| SCHEMBL8477649 | 0.86 | HTR2C (0.69) | HTR2CHTR2AHTR2BCYP1A2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0807104-A2 | HETEROCYCLIC COMPOUNDS POSSESSING 5HT 2C? RECEPTOR ANTAGONIST ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1997-11-19 | — | — | EP | claimed |
| WO-1996023769-A2 | HETEROCYCLIC COMPOUNDS POSSESSING 5HT2C RECEPTOR ANTAGONIST ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1996-08-08 | — | — | WO | claimed |
| US-5972937-A | Heterocyclic compounds possessing 5HT2C receptor antagonist activity | SMITHKLINE BEECHAM P.L.C. (GB) | 1999-10-26 | — | — | US | disclosed |
| EP-0807104-A2 | HETEROCYCLIC COMPOUNDS POSSESSING 5HT 2C? RECEPTOR ANTAGONIST ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1997-11-19 | — | — | EP | disclosed |
| WO-1996023769-A2 | HETEROCYCLIC COMPOUNDS POSSESSING 5HT2C RECEPTOR ANTAGONIST ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1996-08-08 | — | — | WO | disclosed |