Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 20/20 | 0.69 |
| ▸ | HTR2A | P28223 | 17/20 | 0.69 |
| ▸ | HTR2B | P41595 | 9/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.68 |
| ▸ | MAPT | P10636 | 1/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8472115 | 0.86 | HTR2C (0.78) | HTR2CHTR2AHTR2BCYP1A2MEN1 | |
| SCHEMBL7078072 | 0.85 | HTR2C (0.71) | HTR2CHTR2AHTR2BCYP1A2MEN1 | |
| SCHEMBL8476174 | 0.84 | HTR2C (0.70) | HTR2CHTR2AHTR2BCYP1A2MEN1 | |
| SCHEMBL8474911 | 0.83 | HTR2C (0.68) | HTR2CHTR2AHTR2BCYP1A2MEN1 | |
| SCHEMBL8477651 | 0.82 | HTR2C (0.67) | HTR2CHTR2AHTR2BCYP1A2MEN1 | |
| SCHEMBL8472378 | 0.81 | HTR2C (0.64) | HTR2CHTR2AHTR2BCYP1A2MEN1 | |
| SCHEMBL8431394 | 0.81 | HTR2C (1.00) | HTR2CHTR2AHTR2BCYP1A2MEN1 | |
| SCHEMBL29766909 | 0.81 | HTR2C (1.00) | HTR2CHTR2AHTR2BCYP1A2MEN1 | |
| SCHEMBL7078088 | 0.81 | HTR2C (0.79) | HTR2CHTR2AHTR2BCYP1A2MEN1 | |
| SCHEMBL8472170 | 0.81 | HTR2C (0.69) | HTR2CHTR2AHTR2BCYP1A2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5972937-A | Heterocyclic compounds possessing 5HT2C receptor antagonist activity | SMITHKLINE BEECHAM P.L.C. (GB) | 1999-10-26 | — | — | US | claimed |
| WO-1996023769-A2 | HETEROCYCLIC COMPOUNDS POSSESSING 5HT2C RECEPTOR ANTAGONIST ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1996-08-08 | — | — | WO | claimed |
| US-5972937-A | Heterocyclic compounds possessing 5HT2C receptor antagonist activity | SMITHKLINE BEECHAM P.L.C. (GB) | 1999-10-26 | — | — | US | disclosed |
| WO-1996023769-A2 | HETEROCYCLIC COMPOUNDS POSSESSING 5HT2C RECEPTOR ANTAGONIST ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1996-08-08 | — | — | WO | disclosed |