SCHEMBL8472844

SCHEMBL8472844

Nc1ccc2[nH]c(-c3ccc(F)cc3)nc2c1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 6/20 0.63
KMT2A Q03164 6/20 0.63
RXFP1 Q9HBX9 3/20 0.63
CACNA1B Q00975 1/20 0.63
APBA1 Q02410 1/20 0.63
KDM4E B2RXH2 8/20 0.61
ALDH1A1 P00352 8/20 0.61
SMN1; SMN2 Q16637 7/20 0.61
NPC1 O15118 7/20 0.61
RAB9A P51151 7/20 0.61
MAPT P10636 6/20 0.61
GAA P10253 5/20 0.61
GLA P06280 4/20 0.61
GFER P55789 4/20 0.61
RECQL P46063 2/20 0.61
HPGD P15428 5/20 0.58
HSD17B10 Q99714 4/20 0.58
POLB P06746 4/20 0.58
NFKB1 P19838 2/20 0.58
PKM P14618 2/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL3201968 0.98 MEN1 (0.61) MEN1KMT2ARXFP1CACNA1BAPBA1
SCHEMBL30533210 0.92 MEN1 (0.73) MEN1KMT2ARXFP1CACNA1BAPBA1
SCHEMBL1655753 0.92 MEN1 (0.73) MEN1KMT2ARXFP1CACNA1BAPBA1
SCHEMBL6247115 0.90 SMN1; SMN2 (0.61) MEN1KMT2ARXFP1CACNA1BAPBA1
SCHEMBL30307784 0.90 ALDH1A1 (0.74) MEN1KMT2ARXFP1CACNA1BAPBA1
SCHEMBL28312335 0.90 ALDH1A1 (0.74) MEN1KMT2ARXFP1CACNA1BAPBA1
SCHEMBL8769051 0.90 MEN1 (0.71) MEN1KMT2ARXFP1CACNA1BAPBA1
SCHEMBL159873 0.90 ALDH1A1 (0.74) MEN1KMT2ARXFP1CACNA1BAPBA1
SCHEMBL10002475 0.87 ALDH1A1 (0.71) MEN1KMT2ARXFP1CACNA1BAPBA1
SCHEMBL4373640 0.86 KDM4E (0.69) MEN1KMT2ARXFP1CACNA1BAPBA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4733300-A1 NOVEL CHROMENE-BENZIMIDAZOLE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND USE THEREOF Korea University Research and Business Foundation (KR) 2026-04-29 EP disclosed
WO-2024263007-A1 NOVEL CHROMENE-BENZIMIDAZOLE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND USE THEREOF 고려대학교 산학협력단 2024-12-26 WO disclosed
EP-1905764-A1 Substituted 2-Phenyl-benzimidazoles and their use as pharmaceuticals Sanofi-Aventis (FR) 2008-04-02 EP disclosed