Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRNP | P04156 | 7/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 5/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ELANE | P08246 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL862262 | 0.76 | PRNP (0.52) | PRNPRXFP1NPSR1TSHRL3MBTL1 | |
| SCHEMBL857677 | 0.75 | TYMS (0.53) | PRNPRXFP1NPSR1TSHRL3MBTL1 | |
| SCHEMBL28702281 | 0.73 | ALDH1A1 (0.63) | PRNPRXFP1NPSR1TSHRL3MBTL1 | |
| SCHEMBL860937 | 0.73 | TYMS (0.50) | PRNPRXFP1NPSR1TSHRL3MBTL1 | |
| SCHEMBL845526 | 0.72 | ALDH1A1 (0.47) | PRNPRXFP1NPSR1TSHRL3MBTL1 | |
| SCHEMBL845616 | 0.72 | ALDH1A1 (0.47) | PRNPRXFP1NPSR1TSHRL3MBTL1 | |
| SCHEMBL17141930 | 0.67 | ALDH1A1 (0.63) | PRNPRXFP1NPSR1TSHRL3MBTL1 | |
| SCHEMBL30958038 | 0.67 | PRNP (0.63) | PRNPRXFP1NPSR1TSHRL3MBTL1 | |
| SCHEMBL16181940 | 0.67 | ALDH1A1 (0.70) | RXFP1NPSR1TSHRPOLBALDH1A1 | |
| SCHEMBL28382106 | 0.67 | ALDH1A1 (0.61) | PRNPRXFP1NPSR1TSHRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2432774-A2 | COMPOUNDS, COMPOSITIONS AND METHODS FOR MODULATING URIC ACID LEVELS | Ardea Biosciences, Inc. (US) | 2012-03-28 | — | — | EP | disclosed |
| WO-2010135530-A2 | COMPOUNDS, COMPOSITIONS AND METHODS FOR MODULATING URIC ACID LEVELS | ARDEA BIOSCIENCES, INC. (US) | 2010-11-25 | — | — | WO | disclosed |