Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3258317 | 0.79 | POLB (0.39) | POLBEPHX1MEN1KMT2ADPP4 | |
| SCHEMBL24543407 | 0.77 | DPP4 (0.43) | POLBEPHX1MEN1KMT2ADPP4 | |
| SCHEMBL4532611 | 0.77 | POLB (0.43) | POLBEPHX1MEN1KMT2AALDH1A1 | |
| SCHEMBL12234218 | 0.77 | DPP4 (0.43) | POLBEPHX1MEN1KMT2ADPP4 | |
| SCHEMBL13164141 | 0.77 | DPP4 (0.43) | POLBEPHX1MEN1KMT2ADPP4 | |
| SCHEMBL9962281 | 0.75 | DPP4 (0.48) | POLBEPHX1MEN1KMT2ADPP4 | |
| SCHEMBL4956469 | 0.75 | DPP4 (0.48) | POLBEPHX1MEN1KMT2ADPP4 | |
| SCHEMBL24543151 | 0.73 | MAPT (0.39) | POLBEPHX1MEN1KMT2ADPP4 | |
| SCHEMBL24543155 | 0.73 | POLB (0.35) | POLBEPHX1MEN1KMT2ADPP4 | |
| SCHEMBL23975825 | 0.73 | DPP4 (0.47) | POLBEPHX1MEN1KMT2ADPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5902819-A | Triazole derivatives | MERCK SHARP & DOHME LTD. (GB) | 1999-05-11 | — | — | US | disclosed |
| EP-0741722-A1 | TRIAZOLE DERIVATIVES | MERCK SHARP & DOHME LTD. (GB) | 1996-11-13 | — | — | EP | disclosed |
| EP-0651749-A1 | IMIDAZOLE, TRIAZOLE AND TETRAZOLE DERIVATIVES | MERCK SHARP & DOHME LTD. (GB) | 1995-05-10 | — | — | EP | disclosed |
| EP-0637307-A1 | IMIDAZOLE, TRIAZOLE AND TETRAZOLE DERIVATIVES | MERCK SHARP & DOHME LTD. (GB) | 1995-02-08 | — | — | EP | disclosed |
| EP-0630374-A1 | IMIDAZOLE, TRIAZOLE AND TETRAZOLE DERIVATIVES | MERCK SHARP & DOHME LTD. (GB) | 1994-12-28 | — | — | EP | disclosed |
| WO-1993020066-A1 | IMIDAZOLE, TRIAZOLE AND TETRAZOLE DERIVATIVES | MERCK SHARP & DOHME LIMITED (GB) | 1993-10-14 | — | — | WO | disclosed |