Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 8/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL846355 | 0.90 | TRPV1 (0.71) | TRPV1KDM4ERAB9ANPC1SMN1; SMN2 | |
| SCHEMBL847137 | 0.85 | TRPV1 (1.00) | TRPV1KDM4ERAB9ANPC1ALDH1A1 | |
| SCHEMBL846061 | 0.85 | TRPV1 (1.00) | TRPV1KDM4ERAB9ANPC1ALDH1A1 | |
| SCHEMBL847641 | 0.83 | TRPV1 (0.98) | TRPV1KDM4ERAB9ANPC1ALDH1A1 | |
| SCHEMBL847392 | 0.81 | TRPV1 (0.53) | TRPV1KDM4ERAB9ANPC1SMN1; SMN2 | |
| SCHEMBL846736 | 0.80 | TRPV1 (0.71) | TRPV1KDM4ERAB9ANPC1SMN1; SMN2 | |
| SCHEMBL847203 | 0.80 | TRPV1 (0.71) | TRPV1KDM4ERAB9ANPC1SMN1; SMN2 | |
| SCHEMBL28188767 | 0.79 | HDAC1 (0.67) | KDM4ERAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL847628 | 0.79 | TRPV1 (0.81) | TRPV1KDM4ERAB9ANPC1SMN1; SMN2 | |
| SCHEMBL845817 | 0.78 | TRPV1 (0.74) | TRPV1KDM4ERAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603883-B1 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-28 | — | — | EP | disclosed |
| EP-2308848-A1 | Quinoline-derived amide modulators of vanilloid VR1 receptor | Janssen Pharmaceutica NV (BE) | 2011-04-13 | — | — | EP | disclosed |