Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL846356 | 0.90 | MEN1 (0.54) | TRPV1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL846060 | 0.85 | TRPV1 (0.72) | TRPV1RAB9ANPC1SMN1; SMN2KDM4E | |
| SCHEMBL847005 | 0.85 | TRPV1 (0.72) | TRPV1RAB9ANPC1SMN1; SMN2KDM4E | |
| SCHEMBL847493 | 0.84 | TRPV1 (0.70) | TRPV1RAB9ANPC1SMN1; SMN2KDM4E | |
| SCHEMBL846737 | 0.81 | TRPV1 (0.50) | TRPV1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL847391 | 0.81 | TRPV1 (0.73) | TRPV1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL28188767 | 0.80 | HDAC1 (0.67) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL847627 | 0.80 | TRPV1 (0.62) | TRPV1RAB9ANPC1SMN1; SMN2HSD17B10 | |
| SCHEMBL845816 | 0.79 | KDR (0.56) | TRPV1RAB9ANPC1SMN1; SMN2HSD17B10 | |
| SCHEMBL845852 | 0.78 | MEN1 (0.57) | TRPV1HDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603883-B1 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-28 | — | — | EP | disclosed |
| EP-2308848-A1 | Quinoline-derived amide modulators of vanilloid VR1 receptor | Janssen Pharmaceutica NV (BE) | 2011-04-13 | — | — | EP | disclosed |