Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 8/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.62 |
| ▸ | HTR2A | P28223 | 2/20 | 0.62 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.59 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.58 |
| ▸ | HRH1 | P35367 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8494118 | 0.92 | SIGMAR1 (0.84) | SIGMAR1ADRA2AHTR2ATMEM97OPRM1 | |
| SCHEMBL3995859 | 0.83 | SIGMAR1 (0.71) | SIGMAR1ADRA2AHTR2A | |
| SCHEMBL3919858 | 0.83 | SIGMAR1 (0.71) | SIGMAR1ADRA2AHTR2A | |
| SCHEMBL2360456 | 0.78 | SIGMAR1 (0.63) | SIGMAR1 | |
| SCHEMBL3026877 | 0.77 | SIGMAR1 (0.63) | SIGMAR1 | |
| SCHEMBL8473488 | 0.76 | SIGMAR1 (0.78) | SIGMAR1ADRA2AHTR2AHRH1 | |
| SCHEMBL31644147 | 0.75 | SIGMAR1 (0.60) | SIGMAR1ADRA2AHTR2ATMEM97OPRM1 | |
| SCHEMBL8471191 | 0.74 | SIGMAR1 (0.77) | SIGMAR1ADRA2AHTR2AHRH1 | |
| SCHEMBL3008580 | 0.74 | — | — | |
| SCHEMBL2360268 | 0.72 | SIGMAR1 (0.57) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1847542-A1 | Spiro[benzopyran] or spiro[benzofuran] derivatives which inhibit the sigma receptor | Laboratorios del Dr. Esteve S.A. (ES) | 2007-10-24 | — | — | EP | disclosed |