Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.49 |
| ▸ | TDO2 | P48775 | 1/20 | 0.49 |
| ▸ | BRD2 | P25440 | 2/20 | 0.47 |
| ▸ | EDNRA | P25101 | 5/20 | 0.46 |
| ▸ | EDNRB | P24530 | 4/20 | 0.46 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 4/20 | 0.45 |
| ▸ | CA2 | P00918 | 4/20 | 0.45 |
| ▸ | CA7 | P43166 | 4/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.45 |
| ▸ | CA4 | P22748 | 3/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CA3 | P07451 | 1/20 | 0.45 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8479976 | 0.92 | BRD4 (0.47) | BRD4TDO2BRD2EDNRAEDNRB | |
| SCHEMBL8473322 | 0.90 | PTGS2 (0.46) | BRD4BRD2BRD3CA1CA2 | |
| SCHEMBL8479007 | 0.89 | EDNRB (0.46) | BRD4TDO2BRD2EDNRAEDNRB | |
| SCHEMBL8799988 | 0.87 | BRD4 (0.49) | BRD4TDO2BRD2EDNRAEDNRB | |
| SCHEMBL8478608 | 0.86 | POLB (0.48) | BRD4BRD2BRD3ALOX5APFEN1 | |
| SCHEMBL8479990 | 0.83 | PTGS2 (0.40) | BRD4BRD2EDNRAEDNRBBRD3 | |
| SCHEMBL8525140 | 0.83 | MAPK10 (0.40) | EDNRAEDNRBCA1CA2CA7 | |
| SCHEMBL31598837 | 0.82 | EDNRA (0.47) | EDNRAEDNRB | |
| SCHEMBL8674510 | 0.82 | EDNRA (0.47) | EDNRAEDNRB | |
| SCHEMBL8474214 | 0.81 | BRD4 (0.47) | BRD4BRD2EDNRAEDNRBBRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5859257-A | ANTIINFLAMMATORY, ANTIARTHRITIC AGENTS | G. D. SEARLE & CO. (US) | 1999-01-12 | — | — | US | disclosed |