Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.38 |
| ▸ | TTPA | P49638 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10281136 | 0.86 | MAPT (0.59) | MAPTMEN1KMT2ATDP1PPARG | |
| SCHEMBL8470929 | 0.84 | MAPT (0.42) | MAPTMEN1KMT2ATDP1PPARG | |
| SCHEMBL8473756 | 0.84 | MAPT (0.42) | MAPTMEN1KMT2ATDP1PPARG | |
| Hydrochloric Acid SCHEMBL8472181 | 0.84 | MAPT (0.41) | MAPTMEN1KMT2ATDP1PPARG | |
| Maleic Acid SCHEMBL8472381 | 0.81 | MAPT (0.39) | MAPTMEN1KMT2ATDP1PPARG | |
| SCHEMBL8003203 | 0.80 | MAPT (0.64) | MAPTMEN1KMT2ATDP1PPARG | |
| SCHEMBL9632803 | 0.78 | MAPT (0.57) | MAPTMEN1KMT2ATDP1PPARG | |
| Troglitazone SCHEMBL5672808 | 0.78 | MEN1 (0.64) | MAPTMEN1KMT2ATDP1PPARG | |
| Troglitazone SCHEMBL15888838 | 0.78 | MEN1 (0.64) | MAPTMEN1KMT2ATDP1PPARG | |
| Troglitazone SCHEMBL1536757 | 0.78 | MEN1 (0.64) | MAPTMEN1KMT2ATDP1PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5708012-A | Use of thiazolidinedione derivatives and related antihyperglycemic agents in the treatment of insulin resistant subjects with normal glucose tolerance in order to prevent or delay the onset of noninsulin-dependent mellitus | SANKYO COMPANY, LIMITED (JP) | 1998-01-13 | — | — | US | claimed |
| US-5952356-A | TREATING DIABETES IN A MAMMAL WITH AN ACTIVE MATERIAL AND A GLUCOSIDASE INHIBITOR | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-09-14 | — | — | US | disclosed |
| US-5874454-A | Use of thiazolidinedione derivatives in the treatment of polycystic ovary syndrome, gestational diabetes and disease states at risk for progressing to noninsulin-dependent diabetes mellitus | WARNER-LAMBERT COMPANY (US) | 1999-02-23 | — | — | US | disclosed |
| US-5708012-A | Use of thiazolidinedione derivatives and related antihyperglycemic agents in the treatment of insulin resistant subjects with normal glucose tolerance in order to prevent or delay the onset of noninsulin-dependent mellitus | SANKYO COMPANY, LIMITED (JP) | 1998-01-13 | — | — | US | disclosed |