SCHEMBL8475369

SCHEMBL8475369

CCCCCc1ccc(-c2c([O])cc(F)c(CCc3cc(F)c(C(F)(F)F)c(F)c3)c2F)c(F)c1

nearest known ligand 0.37

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
RARB P10826 3/20 0.37
DAO P14920 1/20 0.33
FAAH O00519 1/20 0.33
GCGR P47871 1/20 0.32
RARA P10276 1/20 0.32
RARG P13631 1/20 0.32
S1PR1 P21453 1/20 0.32
GPR3 P46089 1/20 0.32
HTR2A P28223 1/20 0.30
KAT8 Q9H7Z6 2/20 0.30
TRPV1 Q8NER1 1/20 0.30
PPARA Q07869 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8473755 0.97 DAO (0.34) RARBDAO
SCHEMBL8470997 0.92 DAO (0.35) DAO
SCHEMBL8473301 0.90 RARB (0.40) RARBGCGRRARARARGS1PR1
SCHEMBL8474353 0.89 DAO (0.36) DAO
SCHEMBL8836753 0.88 RARB (0.40) RARBDAOFAAHRARARARG
SCHEMBL8473242 0.88 DAO (0.36) RARBDAOFAAHRARARARG
SCHEMBL8476679 0.87 RARB (0.35) RARBFAAHGCGRRARARARG
SCHEMBL8473838 0.87 RARB (0.36) RARBGCGRRARARARGGPR3
SCHEMBL8470781 0.85 RARB (0.36) RARBDAOFAAHRARARARG
SCHEMBL8472686 0.84 DAO (0.37) DAOHTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5858270-A Difluorooxymethane derivative and liquid crystal composition CHISSO CORPORATION (JP) 1999-01-12 US disclosed
EP-0786445-A1 DIFLUOROXYMETHANE DERIVATIVE AND LIQUID CRYSTAL COMPOSITION CHISSO CORPORATION (JP) 1997-07-30 EP disclosed