SCHEMBL8475598

SCHEMBL8475598

CC(C)[C@@H]1Nc2cccc3[nH]cc(c23)C[C@@H](C)NC1=O

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRKCD Q05655 4/20 0.72
PRKCG P05129 3/20 0.44
PRKCB P05771 3/20 0.44
PRKCA P17252 3/20 0.44
PRKCH P24723 3/20 0.44
PRKCE Q02156 3/20 0.44
PRKCQ Q04759 3/20 0.44
PRKD3 O94806 2/20 0.44
PRKD1 Q15139 2/20 0.44
PRKCI P41743 1/20 0.44
PRKCZ Q05513 1/20 0.44
DRD2 P14416 3/20 0.35
PARP1 P09874 1/20 0.35
BRD4 O60885 3/20 0.34
CREBBP Q92793 2/20 0.34
TSHR P16473 1/20 0.34
EP300 Q09472 1/20 0.34
KDM4E B2RXH2 1/20 0.34
MEN1 O00255 1/20 0.34
ALDH1A1 P00352 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8189497 1.00 PRKCD (0.72) PRKCDPRKCGPRKCBPRKCAPRKCH
SCHEMBL6862141 0.65 PRKCD (0.53) PRKCDPRKCGPRKCBPRKCAPRKCH
SCHEMBL12580788 0.62 AHR (0.53) PRKCDDRD2PARP1BRD4CREBBP
Indolactum SCHEMBL1278694 0.61 PRKCD (1.00) PRKCDPRKCGPRKCBPRKCAPRKCH
Indolactum SCHEMBL29375485 0.61 PRKCD (1.00) PRKCDPRKCGPRKCBPRKCAPRKCH
Indolactum SCHEMBL1278760 0.61 PRKCD (1.00) PRKCDPRKCGPRKCBPRKCAPRKCH
SCHEMBL10326971 0.61 CREBBP (0.58) PRKCDPARP1BRD4CREBBPEP300
SCHEMBL17677004 0.61 CREBBP (0.58) PRKCDPARP1BRD4CREBBPEP300
SCHEMBL10326481 0.61 CREBBP (0.58) PRKCDPARP1BRD4CREBBPEP300
SCHEMBL31689232 0.61 CREBBP (0.58) PRKCDPARP1BRD4CREBBPEP300

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5955501-A DERIVED FROM PHORBOIDS OF THE DITERPENE- AND BENZOLACTAM-CLASSES. PROCYON PHARMACEUTICALS, INC. (US) 1999-09-21 US disclosed