Indolactum

Indolactum

SCHEMBL29375485

CC(C)[C@H]1C(=O)N[C@H](CO)Cc2c[nH]c3cccc(c23)N1C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
PRKCD Q05655 18/20 1.00
PRKCA P17252 12/20 1.00
PRKCG P05129 10/20 1.00
PRKCB P05771 9/20 1.00
PRKCE Q02156 9/20 1.00
PRKCH P24723 8/20 1.00
PRKCQ Q04759 8/20 1.00
PRKD3 O94806 3/20 1.00
PRKD1 Q15139 3/20 1.00
PRKCI P41743 2/20 1.00
PRKCZ Q05513 2/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Indolactum SCHEMBL1278760 1.00 PRKCD (1.00) PRKCDPRKCAPRKCGPRKCBPRKCE
Indolactum SCHEMBL1278694 1.00 PRKCD (1.00) PRKCDPRKCAPRKCGPRKCBPRKCE
SCHEMBL25138542 0.90 PRKCD (0.81) PRKCDPRKCAPRKCGPRKCBPRKCE
SCHEMBL26998373 0.87 PRKCD (0.77) PRKCDPRKCAPRKCGPRKCBPRKCE
SCHEMBL29885447 0.87 PRKCD (0.76) PRKCDPRKCAPRKCGPRKCBPRKCE
SCHEMBL31662410 0.83 PRKCD (1.00) PRKCDPRKCAPRKCGPRKCBPRKCE
SCHEMBL25138772 0.83 PRKCD (1.00) PRKCDPRKCAPRKCGPRKCBPRKCE
SCHEMBL30010317 0.83 PRKCD (1.00) PRKCDPRKCAPRKCGPRKCBPRKCE
SCHEMBL29783196 0.82 PRKCD (0.78) PRKCDPRKCAPRKCGPRKCBPRKCE
SCHEMBL30010733 0.77 PRKCD (1.00) PRKCDPRKCAPRKCGPRKCBPRKCE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 141 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12522804-B2 Method for producing pancreatic β cells KANEKA CORPORATION (JP) 2026-01-13 US claimed
US-20250092360-A1 METHODS AND COMPOSITIONS FOR GENERATING SOMATOSTATIN+ INTERNEURONS FROM HUMAN FOREBRAIN NEURAL PROGENITOR CELLS TRAILHEAD BIOSYSTEMS INC. 2025-03-20 US claimed
WO-2024151804-A2 METHODS AND MATERIALS FOR GENERATING STEM CELL-DERIVED ENDOCRINE CELL TYPES MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) 2024-07-18 WO claimed
US-11987813-B2 Microenvironments for self-assembly of islet organoids from stem cells differentiation The Research Foundation for The Sate University of New York (US) 2024-05-21 US claimed
EP-3825397-B1 METHOD FOR PRODUCING PARASYMPATHETIC NEURONS AIST (JP) 2023-04-19 EP claimed
WO-2023033128-A1 METHOD FOR PRODUCING PROTEIN 国立大学法人京都大学 2023-03-09 WO claimed
US-20220226281-A1 COMPOUNDS FOR USE IN ANTI-CANCER IMMUNOTHERAPY SIRENAS LLC (US) 2022-07-21 US claimed
EP-3594323-B1 METHODS AND COMPOSITIONS FOR GENERATING PANCREATIC PROGENITORS AND FUNCTIONAL BETA CELLS FROM HPSCS UNIV HEALTH NETWORK (CA) 2026-05-27 EP disclosed
CN-116836960-B Bifunctional enzyme PAI2 with C-N bond and N-N bond synthesis capability, and preparation method and application thereof QINGDAO INSTITUTE OF BIOENERGY AND BIOPROCESS TECHNOLOGY, CHINESE ACADEMY OF SCIENCES (CN) 2026-05-26 CN disclosed
US-12624342-B2 Methods for reprogramming cells and uses thereof GENESIS TECHNOLOGIES LIMITED (BB) 2026-05-12 US disclosed
EP-4471790-B1 SYSTEM AND METHOD FOR DETERMINING MICROBIOME FROM HOST METABOLOME USING A MACHINE LEARNING MODEL MICROBIOTX HEALTH PRIVATE LTD (IN) 2026-04-01 EP disclosed
EP-4691479-A2 GENERATION OF HUMAN PLURIPOTENT STEM CELL DERIVED FUNCTIONAL BETA CELLS SHOWING A GLUCOSE-DEPENDENT MITOCHONDRIAL RESPIRATION AND TWO-PHASE INSULIN SECRETION RESPONSE Janssen Biotech, Inc. (US) 2026-02-11 EP disclosed
US-12522804-B2 Method for producing pancreatic β cells KANEKA CORPORATION (JP) 2026-01-13 US disclosed
WO-2022058758-A1 DISCONNECTION AGENTS DC EUROPA LIMITED (GB) 2022-03-24 WO disclosed
EP-3964210-A1 METHODS AND COMPOSITIONS FOR TREATMENT OF ALZHEIMER'S DISEASE Neurotrope Bioscience, Inc. (US) 2022-03-09 EP disclosed
EP-3954759-A1 USE OF SMALL MOLECULES TO ENHANCE MAFA EXPRESSION IN PANCREATIC ENDOCRINE CELLS Janssen Biotech, Inc. (US) 2022-02-16 EP disclosed
CN-114040966-A Method for producing insulin-producing cell using dihydroindolizinone derivative 国立大学法人东京工业大学 2022-02-11 CN disclosed
EP-3946411-A1 COMPOSITIONS AND METHODS FOR GENETICALLY-ENCODED HIGH VOLTAGE-ACTIVATED CALCIUM CHANNEL BLOCKERS USING ENGINEERED UBIQUITIN LIGASES The Trustees of Columbia University in the City of New York (US) 2022-02-09 EP disclosed
EP-3950933-A1 CELL POPULATION INCLUDING PLURIPOTENT STEM CELLS AND PRODUCTION METHOD THEREOF Kaneka Corporation (JP) 2022-02-09 EP disclosed
US-20220033493-A1 COMPOSITIONS AND METHODS FOR GENETICALLY-ENCODED HIGH VOLTAGE-ACTIVATED CALCIUM CHANNEL BLOCKERS USING ENGINEERED UBIQUITIN LIGASES THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK 2022-02-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12624342-B2 Methods for reprogramming cells and uses thereof DNMT3B, TRDMT1, MECP2 PRKCD 2194/4885PRKCA 1578/4885PRKCG 2696/4885
US-20220226281-A1 COMPOUNDS FOR USE IN ANTI-CANCER IMMUNOTHERAPY NFATC1, PRKCQ, PRKCZ PRKCD 11/4885PRKCA 8/4885PRKCG 9/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.