SCHEMBL8478124

SCHEMBL8478124

Cc1nc(OCc2c(Cl)ccc(N(C)C(=O)CN)c2Cl)c2ccccc2n1

nearest known ligand 0.54

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.45
BDKRB2 P30411 9/20 0.43
MEN1 O00255 1/20 0.43
MAPT P10636 1/20 0.43
PKM P14618 1/20 0.43
KMT2A Q03164 1/20 0.43
RXFP1 Q9HBX9 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8481022 0.85 BDKRB2 (0.45) BDKRB2
SCHEMBL8479642 0.85 BDKRB2 (0.45) BDKRB2
SCHEMBL8479725 0.83 BDKRB2 (0.43) BDKRB2
SCHEMBL8477637 0.81 BDKRB2 (0.42) BDKRB2
SCHEMBL9233215 0.80 BDKRB2 (0.43) BDKRB2
SCHEMBL8414620 0.79 HTT (0.47) LMNABDKRB2MAPT
SCHEMBL8589062 0.78 BDKRB2 (0.43) BDKRB2
SCHEMBL7748022 0.76 BDKRB2 (0.63) BDKRB2
SCHEMBL7748578 0.76 BDKRB2 (0.64) BDKRB2
SCHEMBL7748037 0.76 BDKRB2 (0.55) BDKRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5922711-A ANTIALLERGENS, ANTIINFLAMMATORY AGENTS, AUTOIMMUNE DISEASES, SHOCK OR ANALGESICS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1999-07-13 US disclosed
US-5708173-A PREPARATION OF SUBSTITUTED QUINOLINE COMPOUNDS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1998-01-13 US disclosed