Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 5/20 | 0.47 |
| ▸ | CDK8 | P49336 | 4/20 | 0.47 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 2/20 | 0.45 |
| ▸ | PLK4 | O00444 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | PRKCG | P05129 | 1/20 | 0.45 |
| ▸ | INSR | P06213 | 1/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | FES | P07332 | 1/20 | 0.45 |
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
| ▸ | ROS1 | P08922 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.45 |
| ▸ | FER | P16591 | 1/20 | 0.45 |
| ▸ | FLT1 | P17948 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3350898 | 0.79 | MAPK8 (0.52) | AXLCDK8TNIKJAK2PLK4 | |
| SCHEMBL3346583 | 0.77 | AXL (0.44) | AXLCDK8TNIKJAK2PLK4 | |
| SCHEMBL13504976 | 0.76 | AXL (0.42) | AXLCDK8TNIKJAK2PLK4 | |
| SCHEMBL3354820 | 0.75 | ALK (0.60) | AXLCDK8TNIKMAPK8 | |
| SCHEMBL16587424 | 0.74 | SGK1 (0.71) | AXLCDK8TNIKPLK4AURKA | |
| SCHEMBL8942760 | 0.74 | CAMKK2 (0.63) | AXLCDK8TNIKPLK4AURKA | |
| SCHEMBL12338414 | 0.70 | PDPK1 (0.40) | AXLCDK8TNIKJAK2PLK4 | |
| SCHEMBL12338409 | 0.70 | DYRK1A (0.37) | AXLCDK8TNIKJAK2PLK4 | |
| SCHEMBL12663657 | 0.69 | AXL (0.39) | AXLCDK8TNIKJAK2PLK4 | |
| SCHEMBL12663655 | 0.69 | AXL (0.44) | AXLCDK8TNIKPLK4AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1749829-B1 | JNK inhibitors | EISAI R&D MAN CO LTD (JP) | 2010-11-03 | — | — | EP | disclosed |