Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 9/20 | 0.60 |
| ▸ | PTGS1 | P23219 | 9/20 | 0.60 |
| ▸ | ESR1 | P03372 | 2/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.50 |
| ▸ | MT-CO2 | P00403 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CA3 | P07451 | 1/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | CA4 | P22748 | 1/20 | 0.44 |
| ▸ | CA6 | P23280 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13944767 | 0.85 | PTGS2 (0.46) | PTGS2PTGS1ESR1ESR2MT-CO2 | |
| SCHEMBL4028144 | 0.85 | PTGS2 (0.50) | PTGS2PTGS1ESR1ESR2MT-CO2 | |
| SCHEMBL5322447 | 0.83 | PTGS2 (0.71) | PTGS2PTGS1MT-CO2CA12CA1 | |
| SCHEMBL7913412 | 0.77 | PTGS2 (0.62) | PTGS2PTGS1ESR1ESR2MT-CO2 | |
| SCHEMBL2277199 | 0.75 | PTGS2 (1.00) | PTGS2PTGS1MT-CO2CA12CA1 | |
| SCHEMBL8474342 | 0.75 | PTGS2 (0.48) | PTGS2PTGS1MT-CO2CA12CA1 | |
| SCHEMBL4028141 | 0.74 | PTGS1 (0.45) | PTGS2PTGS1ESR1ESR2MT-CO2 | |
| SCHEMBL10920153 | 0.73 | PTGS1 (0.49) | PTGS2PTGS1MAPTBRD4BRD2 | |
| SCHEMBL9674379 | 0.73 | PTGS1 (0.46) | PTGS2PTGS1ESR1ESR2BRD4 | |
| SCHEMBL5846132 | 0.73 | GSR (0.42) | PTGS2PTGS1MT-CO2CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5859257-A | ANTIINFLAMMATORY, ANTIARTHRITIC AGENTS | G. D. SEARLE & CO. (US) | 1999-01-12 | — | — | US | disclosed |